Effect of Intermittent and Daily Regimens of Minodronic Acid on Bone Metabolism in an Ovariectomized Rat Model of Osteoporosis
| العنوان: | Effect of Intermittent and Daily Regimens of Minodronic Acid on Bone Metabolism in an Ovariectomized Rat Model of Osteoporosis |
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| المؤلفون: | Naoki Kawada, Kazuhito Kawabata, Makoto Tanaka, Yasuo Ochi, Hiroshi Mori, Ryoji Kayasuga, Hiroyuki Yamada |
| المصدر: | Calcified Tissue International. 95:166-173 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | musculoskeletal diseases, Deoxypyridinoline, medicine.medical_specialty, Minodronic acid, Ovariectomy, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Osteoporosis, Bone and Bones, Bone remodeling, chemistry.chemical_compound, Absorptiometry, Photon, Endocrinology, Bone Density, Internal medicine, medicine, Animals, Orthopedics and Sports Medicine, Femur, Bone mineral, Bone Density Conservation Agents, Diphosphonates, business.industry, Imidazoles, X-Ray Microtomography, Bisphosphonate, medicine.disease, Rats, Disease Models, Animal, chemistry, Ovariectomized rat, Female, business |
| الوصف: | The goal of the study was to compare the effects of minodronic acid on bone mineral density (BMD) and bone turnover in a rat ovariectomized (OVX) osteoporosis model, using two intermittent treatment regimens (weekly and 4 continuous days every 4 weeks) and a daily regimen. Female F344 rats (age 14 weeks) underwent ovariectomy or a sham operation. Minodronic acid was orally administered at 0.042, 0.21, and 1.05 mg/kg in the intermittent regimens, and at 0.03 and 0.15 mg/kg in the daily regimen for 12 weeks from the day after surgery. Minodronic acid dose-dependently ameliorated the decreases in areal BMD of the lumbar vertebrae and femur, and volumetric BMD of total and trabecular bone in the distal femur. Minodronic acid also suppressed the increase in urinary deoxypyridinoline levels and reduced serum osteocalcin levels. In bone histomorphometry, all three minodronic acid regimens suppressed OVX-induced increases in bone turnover at the tissue level and ameliorated all structural indices, except that an effect on trabecular thickness only occurred with daily treatment. In conclusion, minodronic acid administered weekly or for 4 continuous days every 4 weeks suppressed increased bone resorption and BMD to a similar extent to that of a similar total dose given daily in a rat OVX model. |
| تدمد: | 1432-0827 0171-967X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05a9a5d9833795a385c66581351fd68 https://doi.org/10.1007/s00223-014-9876-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d05a9a5d9833795a385c66581351fd68 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320827 0171967X |
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