Design and synthesis of benzyl 4-O-lauroyl-α-L-rhamnopyranoside derivatives as antimicrobial agents
| العنوان: | Design and synthesis of benzyl 4-O-lauroyl-α-L-rhamnopyranoside derivatives as antimicrobial agents |
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| المؤلفون: | Nishat Akther, Mohammed Mahbubul Matin, Mohammad M. H. Bhuiyan, Abul K.M.S. Azad |
| المصدر: | Current Chemistry Letters, Vol 6, Iss 1, Pp 31-40 (2016) |
| بيانات النشر: | Growing Science, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Lauroylation, 0301 basic medicine, Antifungal, 030103 biophysics, biology, 010405 organic chemistry, Stereochemistry, medicine.drug_class, Chemistry, Structure activity relationship (SAR), General Chemistry, Antimicrobial agents, Antimicrobial, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, lcsh:Chemistry, 03 medical and health sciences, lcsh:QD1-999, Group (periodic table), Benzyl α-L-rhamnopyranoside, medicine, Organic chemistry, Bacteria |
| الوصف: | Benzyl α-L-rhamnopyranoside, prepared by both conventional and microwave assisted glycosidation techniques, was converted into benzyl 2,3-O-isopropylidene-α-L-rhamnopyranoside which after lauroylation followed by removal of isopropylidene group gave the benzyl 4-O-lauroyl-α-L-rhamnopyranoside in good yield. Several derivatives of benzyl 4-O-lauroyl-α-L-rhamnopyranoside were prepared and assessed in vitro for their antimicrobial activity against ten human pathogenic bacteria and seven fungi. The structure activity relationship (SAR) study revealed that incorporation of 4-O-lauroyl group in rhamnopyranoside frame work along with 2,3-di-O-acyl group increased the antifungal potentiality of the rhamnopyranosides. |
| تدمد: | 1927-730X 1927-7296 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d073ff6742c48ec0d3954797cc9d33b6 https://doi.org/10.5267/j.ccl.2016.10.001 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d073ff6742c48ec0d3954797cc9d33b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1927730X 19277296 |
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