Inhibitory Effects of Butein on Cancer Metastasis and Bioenergetic Modulation
| العنوان: | Inhibitory Effects of Butein on Cancer Metastasis and Bioenergetic Modulation |
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| المؤلفون: | Jen-Kun Cheng, Shih-Chia Liu, Hui-Lung Sun, Chih-Hsin Tang, Nan-Lin Wu, Po-Chuan Wang, Ching-Hu Chung, Shih-Wei Wang, Chieh-Yu Peng, Chi Chen, Yu-Wei Lai |
| المصدر: | Journal of Agricultural and Food Chemistry. 62:9109-9117 |
| بيانات النشر: | American Chemical Society (ACS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Carcinoma, Hepatocellular, Cell Survival, Antineoplastic Agents, Matrix Metalloproteinase Inhibitors, Oxidative Phosphorylation, Metastasis, chemistry.chemical_compound, Adenosine Triphosphate, Chalcones, In vivo, Cell Line, Tumor, medicine, Humans, Cytotoxic T cell, Neoplasm Invasiveness, Glycolysis, Neoplasm Metastasis, Protein kinase B, PI3K/AKT/mTOR pathway, Butein, Liver Neoplasms, General Chemistry, medicine.disease, Urokinase-Type Plasminogen Activator, Matrix Metalloproteinase 9, Biochemistry, chemistry, Cancer cell, Cancer research, Energy Metabolism, General Agricultural and Biological Sciences |
| الوصف: | Tumor metastasis is the major obstacle for cancer treatment. Previous studies have shown that butein exhibits antiangiogenesis property and anticancer effects in different kinds of human cancer cells. However, the effects of butein on metastasis and energy metabolism of cancer cells are mostly unknown. This study showed that butein significantly inhibited invasion of cancer cells without acting in a cytotoxic fashion. It was further demonstrated that butien dramatically suppressed cancer metastasis by an in vivo CAM-intravasation model. Additionally, butein concentration-dependently repressed the expression and activity of matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA). The study indicated that butein may repress MMP-9 and uPA proteolytic activities and subsequently inhibit cancer metastasis via Akt/mTOR/p70S6K translational machinery. Moreover, butein may partly suppress cancer metastasis by down-regulating ATP synthesis via both oxidative and glycolytic metabolism. The results suggest that butein is a potential antimetastatic agent worthy of further development for cancer treatment. |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d156f1fec9ef767017147eaa80475009 https://doi.org/10.1021/jf502370c |
| رقم الأكسشن: | edsair.doi.dedup.....d156f1fec9ef767017147eaa80475009 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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