Low Intensity Focused Ultrasound (LOFU)-mediated Acoustic Immune Priming and Ablative Radiation Therapy for in situ Tumor Vaccines
| العنوان: | Low Intensity Focused Ultrasound (LOFU)-mediated Acoustic Immune Priming and Ablative Radiation Therapy for in situ Tumor Vaccines |
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| المؤلفون: | Fernando Macian, Claudia Gutierrez Chavez, Saurabh Singh, Chandan Guha, Karin A. Skalina |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Combination therapy, medicine.medical_treatment, lcsh:Medicine, Priming (immunology), Cancer immunotherapy, Breast Neoplasms, CD8-Positive T-Lymphocytes, Cancer Vaccines, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Heat shock protein, medicine, Animals, Cytotoxic T cell, lcsh:Science, Prostate cancer, Multidisciplinary, Radiotherapy, business.industry, Immunosurveillance, lcsh:R, Prostatic Neoplasms, Acoustics, medicine.disease, Combined Modality Therapy, Primary tumor, 3. Good health, Radiation therapy, 030104 developmental biology, Ultrasonic Waves, 030220 oncology & carcinogenesis, Cancer research, Tumour immunology, Female, lcsh:Q, business |
| الوصف: | Focal ablative therapies have been primarily used for local tumor ablation. However, they often fail to impact systemic disease. Here we propose the use of low intensity focused ultrasound (LOFU), a noninvasive, nontoxic, conformal therapy, to deliver acoustic stress to the tumor for immune priming. We demonstrate that LOFU significantly induces expression and cell surface localization of heat shock proteins in murine breast (4T1) and prostate adenocarcinoma (TPSA23) cancer cell lines. In vivo LOFU followed by ablative radiation therapy (RT) results in primary tumor cure, upregulation of a cytotoxic immune response and induction of immunological memory by inhibiting secondary tumor growth upon re-challenge with tumor cells. We, therefore, describe a regimen of a combination therapy with noninvasive, acoustic immune priming and ablative radiation therapy to generate an in situ tumor vaccine, induce CD8+ T cells against tumor-associated antigens and provide a viable oncologic treatment option for solid tumors. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bff95a4821897557a2155cc1dc5076 https://doi.org/10.1038/s41598-019-51332-4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d1bff95a4821897557a2155cc1dc5076 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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