Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets
| العنوان: | Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets |
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| المؤلفون: | Aiping Zheng, Nan Liu, Jing Gao, Xiaoxuan Hong, Hui Zhang, Jingru Li, Zengming Wang, Xianfu Li, Boshi Liu, Xiaolu Han, Gao Xiang |
| المصدر: | Pharmaceutical Research |
| بيانات النشر: | Springer US, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Masking (art), Taste, Sucralose, Materials science, Levetiracetam, principal component analysis, Electronic tongue, Drug Compounding, Pharmaceutical Science, Administration, Oral, 02 engineering and technology, electronic tongue, taste-sensing system, Binder jet 3D printing, 030226 pharmacology & pharmacy, Excipients, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Dissolution testing, Palatability, Electronic Nose, instant-dissolving tablets, Pharmacology, Reproducibility, Organic Chemistry, Reproducibility of Results, 021001 nanoscience & nanotechnology, chemistry, Printing, Three-Dimensional, Molecular Medicine, 0210 nano-technology, Biotechnology, medicine.drug, Biomedical engineering, Research Paper, Tablets |
| الوصف: | Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve palatability. Methods A binder jet 3D printer was used to prepare IDTs of levetiracetam. A texture analyzer and dissolution apparatus were used to predict the oral dispersion time and in vitro drug release of IDTs, respectively. The palatability of different formulations was investigated using the ASTREE electronic tongue in combination with the design of experiment and a model for masking bitter taste. Human gustatory sensation tests were conducted to further evaluate the credibility of the results. Results The 3D printed tablets exhibited rapid dispersion ( 90%). The electronic tongue had an excellent ability of taste discrimination, and levetiracetam had a good linear sensing performance based on a partial least square regression analysis. The principal component analysis was used to analyze the signal intensities of different formulations and showed that 2% sucralose and 0.5% spearmint flavoring masked the bitterness well and resembled the taste of corresponding placebo. The results of human gustatory sensation test were consistent with the trend of the electronic tongue evaluation. Conclusions Owing to its objectivity and reproducibility, this technique is suitable for the design and evaluation of palatability in 3D printed IDT development. |
| اللغة: | English |
| تدمد: | 1573-904X 0724-8741 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20881176177873e86f6f2716449f8fd http://europepmc.org/articles/PMC8178150 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d20881176177873e86f6f2716449f8fd |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1573904X 07248741 |
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