Clinical Impact of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Japanese Population in the ADVANCE Registry
| العنوان: | Clinical Impact of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Japanese Population in the ADVANCE Registry |
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| المؤلفون: | Shunichi Yoda, Timothy A. Fairbairn, Tomohiro Sakamoto, Mitsuyasu Terashima, Jonathon Leipsic, Tomohiro Kawasaki, Hiroshi Ito, Junya Shite, Yasutsugu Shiono, Takashi Kubo, Hiromasa Otake, Kazushige Kadota, Bjarne L. Nørgaard, Campbell Rogers, Kavitha Chinnaiyan, Nobuhiro Tanaka, Manesh R. Patel, Koen Nieman, Hironori Kitabata, Daniel S. Berman, Jeroen J. Bax, Yoshihiro Morino, Tetsuya Amano, Gilbert L. Raff, Hitoshi Matsuo, Lynne M. Hurwitz Koweek, Takashi Akasaka |
| المساهمون: | Radiology & Nuclear Medicine |
| المصدر: | Circulation Journal, 83(6), 1293-1301. Japanese Circulation Society Circulation Journal, 83(6), 1293-1301. JAPANESE CIRCULATION SOC Shiono, Y, Matsuo, H, Kawasaki, T, Amano, T, Kitabata, H, Kubo, T, Morino, Y, Yoda, S, Sakamoto, T, Ito, H, Shite, J, Otake, H, Tanaka, N, Terashima, M, Kadota, K, Patel, M R, Nieman, K, Rogers, C, Nørgaard, B L, Bax, J J, Raff, G L, Chinnaiyan, K M, Berman, D S, Fairbairn, T A, Hurwitz Koweek, L M, Leipsic, J & Akasaka, T 2019, ' Clinical Impact of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Japanese Population in the ADVANCE Registry ', Circulation Journal, vol. 83, no. 6, pp. 1293-1301 . https://doi.org/10.1253/circj.CJ-18-1269 |
| بيانات النشر: | Japanese Circulation Society, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | FUNCTIONAL SEVERITY, medicine.medical_specialty, Computed Tomography Angiography, medicine.medical_treatment, STENOSES, Coronary Artery Disease, Fractional flow reserve, CHEST-PAIN, 030204 cardiovascular system & hematology, Revascularization, Coronary artery disease, FFR, 03 medical and health sciences, 0302 clinical medicine, Asian People, Japan, Internal medicine, ARTERY-DISEASE, Humans, Medicine, In patient, Coronary CT angiography, Prospective Studies, Registries, 030212 general & internal medicine, Aged, Aged, 80 and over, OUTCOMES, business.industry, Coronary computed tomography angiography, General Medicine, CARE, MANAGEMENT STRATEGY, Middle Aged, Japanese population, CT ANGIOGRAPHY, medicine.disease, DIAGNOSTIC PERFORMANCE, Fractional Flow Reserve, Myocardial, FFRCT, Cardiology, Core laboratory, Cardiology and Cardiovascular Medicine, business, Mace |
| الوصف: | Background: Coronary computed tomography angiography (cCTA)-derived fractional flow reserve (FFRCT) is a promising diagnostic method for the evaluation of coronary artery disease (CAD). However, clinical data regarding FFRCT in Japan are scarce, so we assessed the clinical impact of using FFRCT in a Japanese population. Methods and Results: The ADVANCE registry is an international prospective FFRCT registry of patients suspected of CAD. Of 5,083 patients, 1,829 subjects enrolled from Japan were analyzed. Demographics, symptoms, cCTA, FFRCT, treatment strategy, and 90-day major cardiovascular events (MACE) were assessed. Reclassification of treatment strategy between cCTA alone and cCTA+FFRCT occurred in 55.8% of site investigations and in 56.9% in the core laboratory analysis. Patients with positive FFR (FFRCT ≤0.80) were less likely to have non-obstructive disease on invasive coronary angiography than patients with negative FFR (FFRCT >0.80) (20.5% vs. 46.1%, P=0.0001). After FFRCT, 67.0% of patients with positive results underwent revascularization, whereas 96.1% of patients with negative FFRCT were medically treated. MACE occurred in 5 patients with positive FFRCT, but none occurred in patients with negative FFRCT within 90 days. Conclusions: In this Japanese population, FFRCT modified the treatment strategy in more than half of the patients. FFRCT showed potential for stratifying patients suspected of CAD properly into invasive or non-invasive management pathways. |
| تدمد: | 1347-4820 1346-9843 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d246d7d832ae41eac991cc8042472395 https://pure.eur.nl/en/publications/217e2b17-02f1-4f08-a2ba-871a779e50ab |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d246d7d832ae41eac991cc8042472395 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474820 13469843 |
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