Effect of growth hormone therapy on thyroid function in isolated growth hormone deficient and short small for gestational age children: a two-year study, including on assessment of the usefulness of the thyrotropin-releasing hormone (TRH) stimulation test
| العنوان: | Effect of growth hormone therapy on thyroid function in isolated growth hormone deficient and short small for gestational age children: a two-year study, including on assessment of the usefulness of the thyrotropin-releasing hormone (TRH) stimulation test |
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| المؤلفون: | Mahoko Furujo, Motoharu Ochi, Yousuke Higuchi, Takahiro Namba, Yuki Ebuchi, Hiroki Tsuchiya, Shoko Fujinaga, Naoko Urata, Toshihide Kubo, Michiko Kishi, Narumi Hara |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism. 33:1417-1423 |
| بيانات النشر: | Walter de Gruyter GmbH, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, endocrine system, medicine.medical_specialty, Time Factors, Adolescent, Hormone Replacement Therapy, Endocrinology, Diabetes and Metabolism, Thyroid Gland, Levothyroxine, Thyrotropin-releasing hormone, 030209 endocrinology & metabolism, Thyroid Function Tests, Growth hormone deficiency, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, TRH stimulation test, Hypothyroidism, Japan, Predictive Value of Tests, Internal medicine, Central hypothyroidism, medicine, Humans, Child, Thyrotropin-Releasing Hormone, Growth Disorders, Retrospective Studies, Human Growth Hormone, business.industry, Infant, Newborn, medicine.disease, Thyroid Diseases, Child, Preschool, Infant, Small for Gestational Age, Pediatrics, Perinatology and Child Health, IGHD, Female, Thyroid function, business, hormones, hormone substitutes, and hormone antagonists, Follow-Up Studies, 030215 immunology, medicine.drug, Hormone |
| الوصف: | Background The relationship between growth hormone (GH)-replacement therapy and the thyroid axis in GH-deficient (GHD) children remains controversial. Furthermore, there have been few reports regarding non-GHD children. We aimed to determine the effect of GH therapy on thyroid function in GHD and non-GHD children and to assess whether thyrotropin-releasing hormone (TRH) stimulation test is helpful for the identification of central hypothyroidism before GH therapy. Methods We retrospectively analyzed data from patients that started GH therapy between 2005 and 2015. The free thyroxine (FT4) and thyroid-stimulating hormone (TSH) concentrations were measured before and during 24 months of GH therapy. The participants were 149 children appropriate for gestational age with GHD (IGHD: isolated GHD) (group 1), 29 small for gestational age (SGA) children with GHD (group 2), and 25 short SGA children (group 3). Results In groups 1 and 2, but not in group 3, serum FT4 concentration transiently decreased. Two IGHD participants exhibited central hypothyroidism during GH therapy, and required levothyroxine (LT4) replacement. They showed either delayed and/or prolonged responses to TRH stimulation tests before start of GH therapy. Conclusions GH therapy had little pharmacological effect on thyroid function, similar changes in serum FT4 concentrations were not observed in participants with SGA but not GHD cases who were administered GH at a pharmacological dose. However, two IGHD participants showed central hypothyroidism and needed LT4 replacement therapy during GH therapy. TRH stimulation test before GH therapy could identify such patients and provoke careful follow-up evaluation of serum FT4 and TSH concentrations. |
| تدمد: | 2191-0251 0334-018X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2afa86e51c355afd3f72e5db64b67bc https://doi.org/10.1515/jpem-2020-0151 |
| رقم الأكسشن: | edsair.doi.dedup.....d2afa86e51c355afd3f72e5db64b67bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910251 0334018X |
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