Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer
| العنوان: | Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer |
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| المؤلفون: | Xiao-Juan Deng, Jian-Ping Chen, Xiang-Lin Hao, Fei Han, Li-Yun Gao, Zhihong Cui, Jia Cao, Wen-bin Liu, Jinyi Liu, Xiao Jiang, Dan-Dan Wang, Hongqiang Chen, Lin Ao |
| المصدر: | Cell Death and Disease, Vol 10, Iss 6, Pp 1-11 (2019) Cell Death & Disease |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Immunology, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Breast cancer, 0302 clinical medicine, Downregulation and upregulation, Medicine, Phosphorylation, lcsh:QH573-671, Lung cancer, Protein kinase B, PI3K/AKT/mTOR pathway, Oncogene, business.industry, lcsh:Cytology, Cancer, Cell Biology, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Signal transduction, business |
| الوصف: | Although TC2N has proven to be an oncogene in lung cancer, its biological function and molecular mechanisms in other cancer still remains unclear. Here, we investigate in breast cancer that TC2N expression is sharply overexpressed in breast cancer specimens compared with normal breast specimens, and the low TC2N expression was associated with advanced stage, lymphatic metastasis, larger tumors and shorter survival time. Upregulation of TC2N significantly restrains breast cancer cell proliferation in vitro and tumor growth in vivo. Mechanistically, TC2N blocks AKT signaling in a PI3K dependent and independent way through weakening the interaction between ALK and p55γ or inhibiting the binding of EBP1 and AKT. To sum up, these results unmask an ambivalent role of TC2N in cancer, providing a promising inhibitor for PI3K-AKT signaling. |
| اللغة: | English |
| تدمد: | 2041-4889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b28d4714cfaab9c2e4c96cd99f7a60 http://link.springer.com/article/10.1038/s41419-019-1663-5 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d2b28d4714cfaab9c2e4c96cd99f7a60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20414889 |
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