Impairment of Angiogenic Activity in the Serum From Patients With Coronary Aneurysms Due to Kawasaki Disease
| العنوان: | Impairment of Angiogenic Activity in the Serum From Patients With Coronary Aneurysms Due to Kawasaki Disease |
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| المؤلفون: | Masaki Kanazawa, Yoichi Kohno, Kouji Higashi, Masaru Terai, Hiromichi Hamada, Takafumi Honda |
| المصدر: | Circulation Journal. 71:1052-1059 |
| بيانات النشر: | Japanese Circulation Society, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Serum, Umbilical Veins, medicine.medical_specialty, Endothelium, Angiogenesis, Prednisolone, Neovascularization, Physiologic, Angiogenesis Inhibitors, Inflammation, Mucocutaneous Lymph Node Syndrome, Severity of Illness Index, Gastroenterology, Dexamethasone, Umbilical vein, Internal medicine, medicine, Humans, Child, Glucocorticoids, Cells, Cultured, Cell Proliferation, Tube formation, Aspirin, Heparin, business.industry, Coronary Aneurysm, Anticoagulants, Immunoglobulins, Intravenous, Infant, General Medicine, medicine.disease, medicine.anatomical_structure, Child, Preschool, Immunology, cardiovascular system, Kawasaki disease, Endothelium, Vascular, Warfarin, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Vasculitis, medicine.drug |
| الوصف: | The inflammatory mediators play an important role in the progression of coronary vasculitis in Kawasaki disease (KD), but effects of KD serum including inflammatory mediators on endothelial cells remain unknown. We hypothesized that serum activity to stimulate in vitro human umbilical vein endothelial cells (HUVEC) tube formation might be impaired in KD.Serum from patients with coronary aneurysms was less active in stimulating HUVEC tube formation than serum from patients without coronary aneurysms or febrile controls. In patients with coronary aneurysms, the reduction in the serum angiogenic activity was documented already before KD treatment (p=0.03 vs healthy controls, p=0.08 vs febrile controls) and enhanced after intravenous immune globulin plus aspirin (p0.001 vs healthy controls, p=0.002 vs febrile controls); both drugs did not affect the assay studied. This reduction was greater in patients who later developed giant aneurysms8 mm compared with those who developed small to moderate aneurysms (p=0.01). The reduced serum angiogenic activity was partly caused by the reduction in the serum activity of stimulating HUVEC proliferation.Serum activity to stimulate HUVEC tube formation was impaired in KD patients who later developed larger coronary aneurysms, which may be associated with the severity of vascular injury. |
| تدمد: | 1347-4820 1346-9843 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b3eaf14f89d1e2de28c4ac4c53fc31 https://doi.org/10.1253/circj.71.1052 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d2b3eaf14f89d1e2de28c4ac4c53fc31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474820 13469843 |
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