Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity
| العنوان: | Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity |
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| المؤلفون: | Donald W. Lawrence, Paul A. Willard, Allyson M. Cochran, Emily C. Matchett, Jacki Kornbluth |
| المصدر: | Frontiers in Physiology, Vol 11 (2020) Frontiers in Physiology |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cell type, Physiology, medicine.medical_treatment, Review, macrophage, ubiquitin ligase, lcsh:Physiology, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Physiology (medical), medicine, Macrophage, innate immunity, Innate immune system, biology, lcsh:QP1-981, Chemistry, phagocytosis, RNF19B, natural killer, Protein subcellular localization prediction, NKLAM, Ubiquitin ligase, Cell biology, 030104 developmental biology, Cytokine, 030220 oncology & carcinogenesis, biology.protein, cytotoxicity, Function (biology) |
| الوصف: | Natural Killer Lytic-Associated Molecule (NKLAM), also designated RNF19B, is a unique member of a small family of E3 ubiquitin ligases. This 14-member group of ligases has a characteristic cysteine-rich RING-IBR-RING (RBR) domain that mediates the ubiquitination of multiple substrates. The consequence of substrate ubiquitination varies, depending on the type of ubiquitin linkages formed. The most widely studied effect of ubiquitination of proteins is proteasome-mediated substrate degradation; however, ubiquitination can also alter protein localization and function. Since its discovery in 1999, much has been deciphered about the role of NKLAM in innate immune responses. We have discerned that NKLAM has an integral function in both natural killer (NK) cells and macrophages in vitro and in vivo. NKLAM expression is required for each of these cell types to mediate maximal killing activity and cytokine production. However, much remains to be determined. In this review, we summarize what has been learned about NKLAM expression, structure and function, and discuss new directions for investigation. We hope that this will stimulate interest in further exploration of NKLAM. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bdb53495dca571d8a94b2558db427d https://www.frontiersin.org/articles/10.3389/fphys.2020.573372/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d2bdb53495dca571d8a94b2558db427d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |