No Effect of an Automated Bolus Calculator in Pediatric Patients with Type 1 Diabetes on Multiple Daily Injections: The Expert Kids Study
| العنوان: | No Effect of an Automated Bolus Calculator in Pediatric Patients with Type 1 Diabetes on Multiple Daily Injections: The Expert Kids Study |
|---|---|
| المؤلفون: | Jesse Vanbesien, Carmen Yoldi, Kurt Kristensen, Sara Van Aken, Raquel Corripio, Jacobo Perez Sanchez, Kristina Casteels, Marta Ramon-Krauel, Koen Vanbrabant, Eva Vandoorne, Jesper Johannesen, Magda Bontinck, Jens Madsen, Irune Goicoechea, Anne Marie Hertz, Kristian Casteels, Amparo Gonzalez-Vergaz, Steffen Fieuws, Lene Kolle Jorgensen, Roque Cardona Hernandez, Carine Devisscher |
| المصدر: | Madsen, J O B, Casteels, K, Fieuws, S, Kristensen, K, Vanbrabant, K, Ramon-Krauel, M & Johannesen, J 2019, ' No Effect of an Automated Bolus Calculator in Pediatric Patients with Type 1 Diabetes on Multiple Daily Injections : The Expert Kids Study ', Diabetes Technology and Therapeutics, vol. 21, no. 6, pp. 322-328 . https://doi.org/10.1089/dia.2019.0064 |
| بيانات النشر: | Mary Ann Liebert Inc, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Blood Glucose, Male, Adolescent, type 1 diabetes, Endocrinology, Diabetes and Metabolism, CHILDREN, METABOLIC-CONTROL, THERAPY, Injections, law.invention, Endocrinology & Metabolism, Endocrinology, Bolus (medicine), PEOPLE, law, GLYCEMIC CONTROL, Diabetes mellitus, ADOLESCENTS, Humans, Hypoglycemic Agents, Insulin, Medicine, Drug Dosage Calculations, Child, Pediatric, Glycated Hemoglobin, COMPLICATIONS, Type 1 diabetes, Science & Technology, Cross-Over Studies, business.industry, Blood Glucose Self-Monitoring, Automated bolus calculator, Multiple daily injections, medicine.disease, Crossover study, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Treatment Outcome, Calculator, Anesthesia, Quality of Life, Female, business, Life Sciences & Biomedicine |
| الوصف: | Background: This multicenter crossover study investigated the potential beneficial effect of an automated bolus calculator (ABC) in children and adolescents with type 1 diabetes (T1D) treated with multiple daily injections (MDI). Methods: Participants were randomized to either begin or end with a 5 months intervention versus their regular treatment regimen (control), separated by a 2 months washout period. During the intervention participants were carefully instructed to use the ABC (Accu-Check Aviva Expert) versus manual insulin calculations during the control period. Participants between 8 and 18 years of age with T1D were recruited from clinics in Denmark, Belgium, and Spain. Inclusion criteria included T1D for >1 year, a minimum of 3 months MDI treatment before inclusion, and HbA1c of 7.5%-11% (57-97 mmol/mol). Improvement in HbA1c was the main outcome, and improved quality of life (QoL) and glucose variability (time spent in target glucose) were secondary outcomes. Results: A total of 65 patients with a mean age of 13.25 years and a mean HbA1c of 8.25% (66.7 mmol/mol) were included. Midway evaluation after 2 months of intervention showed no significant difference from the standard care (0.297, 95% confidence interval [CI]: -0.645 to 0.054; P = 0.10). The difference remained insignificant after the 5 months of intervention (-0.143 [95% CI: -0.558 to 0.272; P = 0.51]). Using the ABC did not change the time spent in target glucose range, nor did it change the QoL. Conclusions: Our study did not demonstrate beneficial additive effects of an ABC in children and adolescents with T1D treated with MDI neither in HbA1c, nor in any other endpoint investigated. ispartof: DIABETES TECHNOLOGY & THERAPEUTICS vol:21 issue:6 pages:322-328 ispartof: location:United States status: published |
| وصف الملف: | |
| تدمد: | 1557-8593 1520-9156 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3395b6d6d224210424c442cde28ab84 https://doi.org/10.1089/dia.2019.0064 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d3395b6d6d224210424c442cde28ab84 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578593 15209156 |
|---|