Puffball‐Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On‐Demand Drug Delivery
| العنوان: | Puffball‐Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On‐Demand Drug Delivery |
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| المؤلفون: | Xin Song, Rujie Sun, Richard Wang, Kun Zhou, Ruoxiao Xie, Junliang Lin, Dimitar Georgiev, Andrei‐Alexandru Paraschiv, Ruibo Zhao, Molly M. Stevens |
| المساهمون: | Rosetrees Trust, Stoneygate Trust, Royal Academy Of Engineering, Engineering and Physical Sciences Research Council |
| المصدر: | Advanced Materials. 34:2204791 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Technology, intelligent microrobots, Infrared Rays, Chemistry, Multidisciplinary, Materials Science, Materials Science, Multidisciplinary, bioinspired systems, magnetic actuation, 09 Engineering, Physics, Applied, Drug Delivery Systems, General Materials Science, Nanoscience & Nanotechnology, Science & Technology, 02 Physical Sciences, Chemistry, Physical, Physics, Mechanical Engineering, MICROMACHINES, Phototherapy, targeted therapy, Chemistry, Drug Liberation, Physics, Condensed Matter, Mechanics of Materials, Physical Sciences, Science & Technology - Other Topics, controlled release, 03 Chemical Sciences, Locomotion |
| الوصف: | Microrobots have been recognized as transformative solutions for drug delivery systems (DDSs) because they can navigate through the body to specific locations and enable targeted drug release. However, their realization is substantially limited by insufficient payload capacity, unavoidable drug leakage/deactivation, and strict modification/stability criteria for drugs. Natural puffballs possess fascinating features that are highly desirable for DDSs, including a large fruitbody for storing spores, a flexible protective cap, and environmentally-triggered release mechanisms. This report presents a puffball-inspired microrobotic system which incorporates: an internal chamber for loading large drug quantities and spatial drug separation; and a near-infrared-responsive top-sealing layer offering strong drug protection and on-demand release. These puffball-inspired microrobots (PIMs) display tunable loading capacities up to high concentrations and enhanced drug protection with minimal drug leakage. Upon near-infrared laser irradiation, on-demand drug delivery with rapid release efficiency is achieved. The PIMs also demonstrate translational motion velocities, switchable motion modes, and precise locomotion under a rotating magnetic field. This work provides strong proof-of-concept for a DDS that combines the superior locomotion capability of microrobots with the unique characteristics of puffballs, thereby illustrating a versatile avenue for development of a new generation of microrobots for targeted drug delivery. |
| تدمد: | 1521-4095 0935-9648 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36df71a6ca0e3c480de25d2dbafce08 https://doi.org/10.1002/adma.202204791 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d36df71a6ca0e3c480de25d2dbafce08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214095 09359648 |
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