Influence of Dietary Supplementation With a Powder Containing A.N. ProDen™ (Ascophyllum Nodosum) Algae on Dog Saliva Metabolome
| العنوان: | Influence of Dietary Supplementation With a Powder Containing A.N. ProDen™ (Ascophyllum Nodosum) Algae on Dog Saliva Metabolome |
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| المؤلفون: | Jacek Wilczak, Jerzy Gawor, Ulla K. Svensson, Michał Jank |
| المصدر: | Frontiers in Veterinary Science, Vol 8 (2021) Frontiers in Veterinary Science |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Saliva, dogs, Veterinary medicine, Physiology, Placebo, ascophyllum, 03 medical and health sciences, Gingivitis, 0302 clinical medicine, Major Salivary Gland, SF600-1100, Metabolome, Medicine, metabolites, Original Research, 030304 developmental biology, 0303 health sciences, saliva, General Veterinary, biology, business.industry, Calculus (dental), 030206 dentistry, biology.organism_classification, medicine.disease, metabolomics, Brown algae, stomatognathic diseases, oral health, Veterinary Science, medicine.symptom, business, Ascophyllum |
| الوصف: | The objective of this placebo-controlled, double-blind, randomized study (designed according to evidence-based medicine standards) was to determine the effect of 30-day administration of powdered brown algae, Ascophyllum nodosum (ProDen PlaqueOff, SwedenCare AB, Sweden), on saliva metabolomes in dogs. Sixty client-owned dogs underwent professional dental cleaning and were randomly subdivided into two groups receiving daily powdered brown algae A. nodosum, or a placebo (microcrystalline cellulose in powder), adjusted to their bodyweight. After a comprehensive oral health assessment and professional dental cleaning, which were both performed under general anesthesia, clinical assessments for gingivitis, plaque, and calculus were conducted. Saliva samples were collected at Day 0 and Day 30 of supplementation. Whole saliva is a mixed fluid that is derived predominantly from the major salivary glands but it also contains numerous other constituents. Additionally, its composition varies on whether salivary secretion is basal or stimulated. Authors put efforts to avoid contamination of saliva by other constituents and character of saliva was basal. Quadrupole time-of-flight (QTOF) mass spectrometer was used to conduct analysis of the saliva samples. Metabolomic analyses identified clear changes after 30 days of supplementation, and the direction of these changes was completely different than in dogs that received a placebo treatment during the same period. The positive clinical effect of 30 days of A. nodosum supplementation on oral health status in dogs described in previous publication combined with the absence of some metabolites in the saliva of dogs on day 30 of supplementation suggest that brown algae inhibit or turn off some pathways that could enhance plaque or calculus development. The exact mechanism of A. nodosum is still unclear and warrants further study. |
| اللغة: | English |
| تدمد: | 2297-1769 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b2e37fd5be36d7540c460fd3a3a780 https://www.frontiersin.org/articles/10.3389/fvets.2021.681951/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d3b2e37fd5be36d7540c460fd3a3a780 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22971769 |
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