Hedgehog Signaling Regulates Neurogenesis in the Larval and Adult Zebrafish Hypothalamus
| العنوان: | Hedgehog Signaling Regulates Neurogenesis in the Larval and Adult Zebrafish Hypothalamus |
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| المؤلفون: | Rita R. Fagan, Christine A. Devine, A. Tuba Ozacar, Matthew D. Loring, Alyssa Lutservitz, Ira Male, Veronica A. Pace, Rolf O. Karlstrom, Grace E. Lawson, Meng-Chieh Shen |
| المصدر: | eNeuro |
| بيانات النشر: | Society for Neuroscience, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | hedgehog, Neurogenesis, Population, Hypothalamus, Development, Biology, Serotonergic, Animals, Hedgehog Proteins, education, Hedgehog, Zebrafish, education.field_of_study, General Neuroscience, Dopaminergic, General Medicine, zebrafish, biology.organism_classification, Hedgehog signaling pathway, Cell biology, Larva, GABAergic, Research Article: New Research, Signal Transduction |
| الوصف: | Visual Abstract Neurogenesis is now known to play a role in adult hypothalamic function, yet the cell-cell mechanisms regulating this neurogenesis remain poorly understood. Here, we show that Hedgehog (Hh)/Gli signaling positively regulates hypothalamic neurogenesis in both larval and adult zebrafish and is necessary and sufficient for normal hypothalamic proliferation rates. Hh-responsive radial glia represent a relatively highly proliferative precursor population that gives rise to dopaminergic, serotonergic, and GABAergic neurons. In situ and transgenic reporter analyses revealed substantial heterogeneity in cell-cell signaling within the hypothalamic niche, with slow cycling Nestin-expressing cells residing among distinct and overlapping populations of Sonic Hh (Shh)-expressing, Hh-responsive, Notch-responsive, and Wnt-responsive radial glia. This work shows for the first time that Hh/Gli signaling is a key component of the complex cell-cell signaling environment that regulates hypothalamic neurogenesis throughout life. |
| تدمد: | 2373-2822 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d49a2aaed40a0d721a9e95e4aa69ff https://doi.org/10.1523/eneuro.0226-20.2020 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d3d49a2aaed40a0d721a9e95e4aa69ff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23732822 |
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