Dynamic host immune response in virus-associated cancers
| العنوان: | Dynamic host immune response in virus-associated cancers |
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| المؤلفون: | Song Cao, Kristine M. Wylie, Matt A. Wyczalkowski, Alla Karpova, Jessica Ley, Sam Sun, R. Jay Mashl, Wen-Wei Liang, Xiaowei Wang, Kimberly Johnson, John F. DiPersio, Hiram Gay, Lee Ratner, Feng Chen, Douglas R. Adkins, Li Ding |
| المصدر: | Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019) Communications Biology |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Epstein-Barr Virus Infections, Virus Integration, Medicine (miscellaneous), Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Virus, Article, B7-H1 Antigen, 03 medical and health sciences, 0302 clinical medicine, Immune system, Downregulation and upregulation, Neoplasms, medicine, Biomarkers, Tumor, Humans, Gastrointestinal cancer, lcsh:QH301-705.5, 030304 developmental biology, 0303 health sciences, Gene Expression Profiling, Papillomavirus Infections, Cancer, medicine.disease, Cell Transformation, Viral, Programmed Cell Death 1 Ligand 2 Protein, Head and neck squamous-cell carcinoma, Immune checkpoint, 3. Good health, Gene Expression Regulation, Neoplastic, lcsh:Biology (General), 030220 oncology & carcinogenesis, Host-Pathogen Interactions, Cancer research, Disease Susceptibility, General Agricultural and Biological Sciences, Carcinogenesis |
| الوصف: | Viruses drive carcinogenesis in human cancers through diverse mechanisms that have not been fully elucidated but include promoting immune escape. Here we investigated associations between virus-positivity and immune pathway alteration for 2009 tumors across six virus-related cancer types. Analysis revealed that for 3 of 72 human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSC) the HPV genome integrated in immune checkpoint genes PD-L1 or PD-L2, driving elevated expression in the corresponding gene. In addition to the previously described upregulation of the PD-1 immunosuppressive pathway in Epstein-Barr virus (EBV)-positive stomach tumors, we also observed upregulation of the PD-1 pathway in cytomegalovirus (CMV)-positive tumors. Furthermore, we found signatures of T-cell and B-cell response in HPV-positive HNSC and EBV-positive stomach tumors and HPV-positive HNSC patients were associated with better survival when T-cell signals were detected. Our work reveals that viral infection may recruit immune effector cells, and upregulate PD-1 and CTLA-4 immunosuppressive pathways. Cao et al. show that human papillomavirus-positive, head and neck squamous cell carcinoma patients are associated with better survival when T-cells are activated. This study suggests that viral infection may recruit immune effector cells and that it may activate PD-1 and CTLA-4 immunosuppressive pathways. |
| اللغة: | English |
| تدمد: | 2399-3642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44af00e65ce0c6741de07e931d35795 http://link.springer.com/article/10.1038/s42003-019-0352-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d44af00e65ce0c6741de07e931d35795 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23993642 |
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