Seroprevalence of anti-SARS-CoV-2 antibodies in women attending antenatal care in eastern Ethiopia: a facility-based surveillance
| العنوان: | Seroprevalence of anti-SARS-CoV-2 antibodies in women attending antenatal care in eastern Ethiopia: a facility-based surveillance |
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| المؤلفون: | Joseph Oundo, Jag Scott, Lemma Demissie Regassa, Yadeta Dessie, Lola Madrid, Zelalem Teklemariam, Nega Assefa |
| المصدر: | BMJ Open, Vol 11, Iss 11 (2021) BMJ Open |
| بيانات النشر: | BMJ Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | protocols & guidelines, Referral, Epidemiology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Convenience sample, Antibodies, Viral, Pregnancy, Seroepidemiologic Studies, District hospital, Humans, Seroprevalence, Infection control, Medicine, Multivariable model, prenatal diagnosis, biology, SARS-CoV-2, business.industry, COVID-19, Prenatal Care, health policy, General Medicine, Hospitals, District, infection control, biology.protein, Female, Ethiopia, Antibody, business, Demography |
| الوصف: | ObjectiveWe conducted serosurveillance of anti-SARS-CoV-2 antibodies among pregnant women attending their first antenatal care.SettingThe surveillance was set in one referral hospital in Harar, one district hospital and one health centre located in Haramaya district in rural eastern Ethiopia.ParticipantsWe collected questionnaire data and a blood sample from 3312 pregnant women between 1 April 2020 and 31 March 2021. We selected 1447 blood samples at random and assayed these for anti-SARS-CoV-2 antibodies at Hararghe Health Research laboratory using WANTAI SARS-CoV-2 Rapid Test for total immunoglobulin.OutcomeWe assayed for anti-SARS-CoV-2 antibodies and temporal trends in seroprevalence were analysed with a χ2 test for trend and multivariable binomial regression.ResultsAmong 1447 sera tested, 83 were positive for anti-SARS-CoV-2 antibodies giving a crude seroprevalence of 5.7% (95% CI 4.6% to 7.0%). Of 160 samples tested in April–May 2020, none was seropositive; the first seropositive sample was identified in June and seroprevalence rose steadily thereafter (χ2 test for trend, p=0.003) reaching a peak of 11.8% in February 2021. In the multivariable model, seroprevalence was approximately 3% higher in first-trimester mothers compared with later presentations, and rose by 0.75% (95% CI 0.31% to 1.20%) per month of calendar time.ConclusionsThis clinical convenience sample illustrates the dynamic of the SARS-CoV-2 epidemic in pregnant women in eastern Ethiopia; infection was rare before June 2020 but it spread in a linear fashion thereafter, rather than following intermittent waves, and reached 10% by the beginning of 2021. After 1 year of surveillance, most pregnant mothers remained susceptible. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2044-6055 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d467f12ecaa7ef6eb771752703a73a53 https://researchonline.lshtm.ac.uk/id/eprint/4664153/1/Assefa_etal_2021_Seroprevalence-of-anti-sars-cov.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d467f12ecaa7ef6eb771752703a73a53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20446055 |
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