Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
العنوان: | Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity |
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المؤلفون: | Ke Xu, Ning-Ning Wang, Yue-Lan Li, Chun-Yu Liu, Hong-Xiang Lou, Tian Wang |
المصدر: | Natural Products and Bioprospecting |
بيانات النشر: | Springer Science and Business Media LLC, 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | Stereochemistry, medicine.drug_class, Plant Science, Toxicology, Biochemistry, Anti-inflammatory, Analytical Chemistry, Anti-inflammatory activity, chemistry.chemical_compound, medicine, Quinazoline, Bioorganic chemistry, Pharmacology, Aspergillus, Quinazoline derivatives, Natural product, biology, Organic Chemistry, Endophytic fungus, biology.organism_classification, Moss, chemistry, Original Article, Food Science |
الوصف: | Abstract Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3–12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5, 7 and 8 showed significant inhibitory effects on NO production, with IC50 values of 49.85, 22.14 and 46.02 μM respectively. Graphic Abstract |
تدمد: | 2192-2209 2192-2195 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c476e6a3dfc4832517af7bd9e924b6 https://doi.org/10.1007/s13659-020-00287-5 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....d4c476e6a3dfc4832517af7bd9e924b6 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 21922209 21922195 |
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