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Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

التفاصيل البيبلوغرافية
العنوان: Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
المؤلفون: Ke Xu, Ning-Ning Wang, Yue-Lan Li, Chun-Yu Liu, Hong-Xiang Lou, Tian Wang
المصدر: Natural Products and Bioprospecting
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Plant Science, Toxicology, Biochemistry, Anti-inflammatory, Analytical Chemistry, Anti-inflammatory activity, chemistry.chemical_compound, medicine, Quinazoline, Bioorganic chemistry, Pharmacology, Aspergillus, Quinazoline derivatives, Natural product, biology, Organic Chemistry, Endophytic fungus, biology.organism_classification, Moss, chemistry, Original Article, Food Science
الوصف: Abstract Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3–12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5, 7 and 8 showed significant inhibitory effects on NO production, with IC50 values of 49.85, 22.14 and 46.02 μM respectively. Graphic Abstract
تدمد: 2192-2209
2192-2195
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c476e6a3dfc4832517af7bd9e924b6
https://doi.org/10.1007/s13659-020-00287-5
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....d4c476e6a3dfc4832517af7bd9e924b6
قاعدة البيانات: OpenAIRE
الوصف
تدمد:21922209
21922195