Using System Identification to Construct an Inherent Model of Pupillary Light Reflex to Explore Diabetic Neuropathy
| العنوان: | Using System Identification to Construct an Inherent Model of Pupillary Light Reflex to Explore Diabetic Neuropathy |
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| المؤلفون: | Mang Ou-Yang, Chien Nan Chen, Yung Jhe Yan |
| المصدر: | Brain Sciences Volume 11 Issue 7 Brain Sciences, Vol 11, Iss 852, p 852 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Sympathetic nervous system, Diabetic neuropathy, 0206 medical engineering, Neurosciences. Biological psychiatry. Neuropsychiatry, 02 engineering and technology, Stimulus (physiology), Article, 03 medical and health sciences, Parasympathetic nervous system, 0302 clinical medicine, Internal medicine, Medicine, Pupillary light reflex, system identification, Diabetic Autonomic Neuropathy, diabetic autonomic neuropathy, business.industry, General Neuroscience, autonomic nervous system, biological system modeling, medicine.disease, 020601 biomedical engineering, body regions, Autonomic nervous system, pupillary light reflex, medicine.anatomical_structure, Dilator, Cardiology, business, 030217 neurology & neurosurgery, RC321-571 |
| الوصف: | This study proposed a pupillary light reflex (PLR) inherent model based on the system identification method to demonstrate the dynamic physiological mechanism of the PLR, in which pupillary constriction and dilation are controlled by the sympathetic and parasympathetic nervous system. This model was constructed and verified by comparing the simulated and predicted PLR response with that of healthy participants. The least root-mean-square error (RMSE) of simulated PLR response was less than 0.7% when stimulus duration was under 3 ms. The RMSE of predicted PLR response increased by approximately 6.76%/s from the stimulus duration of 1 ms to 3 s, when the model directly used the parameters extracted from the PLR at the stimulus duration of 10 ms. When model parameters were derived from the regression by the measured PLR response, the RMSE kept under 8.5%. The model was applied to explore the PLR abnormalities of the people with Diabetic Mellitus (DM) by extracting the model parameters from 42 people with DM and comparing these parameters with those of 42 healthy participants. The parameter in the first-order term of the elastic force of the participants with DM was significantly lower than that of the healthy participants (p < 0.05). The sympathetic force and sympathetic action delay of the participants with DM were significantly larger (p < 0.05) and longer (p < 0.0001) than that of the healthy ones, respectively. The reason might be that the sympathetic nervous system, which controls the dilator muscle, degenerated in diabetic patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3425 |
| DOI: | 10.3390/brainsci11070852 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fd64eaf62e2043e58cff1945f13736 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d4fd64eaf62e2043e58cff1945f13736 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763425 |
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| DOI: | 10.3390/brainsci11070852 |