Effects of dietary ferulic acid supplementation on growth performance and skeletal muscle fiber type conversion in weaned piglets
| العنوان: | Effects of dietary ferulic acid supplementation on growth performance and skeletal muscle fiber type conversion in weaned piglets |
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| المؤلفون: | Bing Yu, Jie Yu, Yuheng Luo, Xiaoling Chen, Youxia Wang, Ping Zheng, Zhiqing Huang, Hong Chen, Jun He, Daiwen Chen |
| المصدر: | Journal of the Science of Food and Agriculture. 101:5116-5123 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Coumaric Acids, Swine, 030309 nutrition & dietetics, Muscle Fibers, Skeletal, Weaning, Malate dehydrogenase, Mitochondrial Proteins, 03 medical and health sciences, 0404 agricultural biotechnology, Malate Dehydrogenase, Internal medicine, Myosin, medicine, Animals, Cytochrome c oxidase, NRF1, Phosphorylation, Muscle, Skeletal, Protein kinase A, 0303 health sciences, Nutrition and Dietetics, Myosin Heavy Chains, biology, Sirtuin 1, Chemistry, Skeletal muscle, 04 agricultural and veterinary sciences, TFAM, 040401 food science, Mitochondria, DNA-Binding Proteins, Endocrinology, medicine.anatomical_structure, Dietary Supplements, biology.protein, Female, Agronomy and Crop Science, Signal Transduction, Transcription Factors, Food Science, Biotechnology |
| الوصف: | Background Ferulic acid (FA) is a common polyphenolic compound. The purpose of this study was to explore the effect of dietary FA supplementation on growth performance and muscle fiber type conversion in weaned piglets. In this study, eighteen 21-day-old DLY (Duroc × Landrace × Yorkshire) weaned piglets were randomly divided into control, 0.05% FA, and 0.45% FA groups. Results Our study showed that dietary FA supplementation had no effect on growth performance, but it could upregulate the expression of slow myosin heavy chain (MyHC) protein, increase the activities of succinic dehydrogenase and malate dehydrogenase, and downregulate the expression of fast MyHC protein. Dietary FA supplementation also increased the expression levels of phosphorylated AMP-activated protein kinase, sirtuin 1 (Sirt1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), myocyte enhancer factor 2C, and troponin I-SS, increased the proportion of slow-twitch fiber, and decreased the proportion of fast-twitch fiber. In addition, our results showed that dietary FA supplementation increased the messenger RNA abundance of mitochondrial nuclear transcription genes, including ATP synthase membrane subunit c locus 1, cytochrome oxidase subunit 1, nuclear respiratory factor 1, mitochondrial transcription factor A, mitochondrial transcription factor B1, and cytochrome c. Conclusion We provided the first evidence that FA could promote muscle fiber type conversion from fast-twitch to slow-twitch via the Sirt1/AMP-activated protein kinase/PGC-1α signaling pathway and could improve the mitochondrial function in weaned piglets. This means that FA can be used as a dietary supplement to improve the quality of pork. © 2021 Society of Chemical Industry. |
| تدمد: | 1097-0010 0022-5142 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5342957efc2a855871638eab1a1c0ac https://doi.org/10.1002/jsfa.11157 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d5342957efc2a855871638eab1a1c0ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970010 00225142 |
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