In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT
| العنوان: | In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT |
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| المؤلفون: | Liwei Liu, Liang Hong, Kun Liu, Yi-Xin Chang, Yue Zhao, Bingling Chen, Ning-Ning Zhang, Rui Hu, Junle Qu, Shaozhuang Yang |
| المصدر: | Journal of Innovative Optical Health Sciences, Vol 12, Iss 1, Pp 1950001-1-1950001-10 (2019) |
| بيانات النشر: | World Scientific Pub Co Pte Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Materials science, brain microcirculation, media_common.quotation_subject, Biomedical Engineering, Medicine (miscellaneous), Spectral domain, 02 engineering and technology, Polyethylene glycol, lcsh:Technology, 01 natural sciences, Microcirculation, 010309 optics, chemistry.chemical_compound, Optical coherence tomography, In vivo, 0103 physical sciences, PEG ratio, medicine, lcsh:QC350-467, Contrast (vision), Mice brain, media_common, medicine.diagnostic_test, lcsh:T, cerebral blood vessels, 021001 nanoscience & nanotechnology, gold nanorods, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, chemistry, 0210 nano-technology, lcsh:Optics. Light, Biomedical engineering |
| الوصف: | In this paper, we proposed a contrast-enhanced homemade spectral domain optical coherence tomography (SD-OCT) method for monitoring of brain microcirculation. We used the polyethylene glycol (PEG)-ylated gold nanorods (GNRs) as a contrast-enhanced agent, obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels. Owing to high scattering of the PEG-GNRs, more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20[Formula: see text]min, the enhancement then declined gradually for 60[Formula: see text]min. Our results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo, especially for studies of the brain microcirculation, which could be serviced for disease mechanism research and therapeutic drug monitoring. |
| تدمد: | 1793-7205 1793-5458 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d542650035ffe537de55426a86677c41 https://doi.org/10.1142/s1793545819500019 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d542650035ffe537de55426a86677c41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17937205 17935458 |
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