Infective endocarditis in Principal Hospital of Dakar: a retrospective study of 42 cases over 10 years
| العنوان: | Infective endocarditis in Principal Hospital of Dakar: a retrospective study of 42 cases over 10 years |
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| المؤلفون: | Fatou Fall, Pape Diadie Fall, Mouhamed Cherif Mboup, Khadidiatou Dia, Djibril Marie Ba, Sara Boury Gning, Nafissatou Zeba, Awa Ndaw Fall |
| المصدر: | The Pan African Medical Journal, Vol 26, Iss 40 (2017) The Pan African Medical Journal |
| بيانات النشر: | African Field Epidemiology Network, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Staphylococcus aureus, 030213 general clinical medicine, medicine.medical_specialty, Adolescent, Prevalence, dakar, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, Endocarditis, Case Series, Hospital Mortality, 030212 general & internal medicine, Child, Aged, Retrospective Studies, fever, lcsh:R5-920, Heart Murmurs, business.industry, lcsh:Public aspects of medicine, Infant, Retrospective cohort study, lcsh:RA1-1270, Endocarditis, Bacterial, General Medicine, Middle Aged, Staphylococcal Infections, medicine.disease, Senegal, Surgery, Embolism, Echocardiography, Child, Preschool, Heart failure, Infective endocarditis, Etiology, endocarditis, Female, business, heart valves, lcsh:Medicine (General) |
| الوصف: | Infective Endocarditis (IE) is an endocardial infection usually caused by bacteria that affects not only the native heart valves but also, with increasing frequency intravascular implanted devices and congenital heart diseases. Despite medical advances, IE remains a life-threatening disease with substantial morbidity and mortality. In Africa, its diagnosis and treatment are still a major challenge in clinical practice. The objective of this work was to study the epidemiological, clinical features, diagnostic techniques currently used in medical practice and the range of micro-organisms that are responsible. This was a retrospective study done at Principal Hospital of Dakar. We include all patients who were admitted with clinical manifestations of definite or possible IE according to the extended DUKE criteria between January 1st, 2005 and December 31st, 2014. We collected and analyzed epidemiological, clinical, paraclinical and outcomes data of 42 patients. Hospital prevalence of IE was 0.078% (42/53711). The mean age was 27.5+/- 18 years with a sex ratio (M/F) of 0.55. IE were more common in patients with damaged or abnormal heart valves (78.6%) and in thoses with underlying structural defects (14.3%). The most common presenting symptoms were fever (90%) and cardiac murmurs (81%). Extracardiac clinical manifestations were very rare. The usual laboratory parameters of inflammation were elevated in 90% of patients. Blood cultures were negative in 50% of cases and positive in 21.4%. The main organism found was Staphylococcus aureus. Echocardiography found vegetations in 95.2% of cases, chamber enlargement in 73.8% and mitral regurgiation in 83.3%. Broad-spectrum penicillins including ampicillin and gentamycine were used for all patients. Major complications were heart failure (47.6%). Strokes and cerebral abcess (23.8%) and Vascular emboli 14.3%. Hospital mortality was 31%. IE remains a life-threatening disease with hight mortality despites improved techniques of diagnosis and modern antibiotics. |
| اللغة: | English |
| تدمد: | 1937-8688 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5aa085374e7ad2cabd0fe6cdb667bd6 https://doaj.org/article/04835e7f9ec147758ad2368de694b5c6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d5aa085374e7ad2cabd0fe6cdb667bd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19378688 |
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