Antiphospholipid antibody positivity in early systemic lupus erythematosus is associated with subsequent vascular events
| العنوان: | Antiphospholipid antibody positivity in early systemic lupus erythematosus is associated with subsequent vascular events |
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| المؤلفون: | Nicola Farina, Ruya Abdulsalam, Thomas McDonnell, Charis Pericleous, Amrita D’Souza, Vera M Ripoll, Jemma Webster, David A Isenberg, Ian Giles, Anisur Rahman |
| المصدر: | Rheumatology. |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Rheumatology, Pharmacology (medical) |
| الوصف: | Objective aPL are found in the blood of 20–30% of patients with SLE. Although aPL cause vascular thrombosis in the antiphospholipid syndrome, it is not clear whether positive aPL levels in early SLE increase risk of subsequent vascular events (VE). In a previous analysis of 276 patients with SLE, we found that early positivity for ≥2 of IgG anti-cardiolipin (anti-CL), IgG anti-β2-glycoprotein I (anti-β2GPI) and anti-domain I of β2-glycoprotein I (anti-DI) showed a possible association with VE. Here we have extended that analysis. Methods Serum samples taken from 501 patients with SLE early in their disease had been tested for IgG anti-CL, anti-β2GPI and anti-DI by ELISA. Complete VE history was available for 423 patients of whom 23 were excluded because VE occurred before the diagnosis of SLE. For the remaining 400 patients we carried out Kaplan–Meier survival analysis to define groups at higher risk of VE. Results Of 400 patients, 154 (38.5%) were positive for one or more aPL, 27 (6.8%) were double/triple-positive and 127 (31.8%) were single-positive. There were 91 VE in 77 patients, of whom 42 were aPL-positive in early disease. VE were significantly increased in aPL-positive vs aPL-negative patients (P = 0.041) and in double/triple-positive vs single-positive vs aPL-negative patients (P = 0.0057). Omission of the IgG anti-DI assay would have missed 14 double/triple-positive patients of whom six had VE. Conclusion Double/triple-positivity for IgG anti-CL, anti-β2GPI and anti-DI in early SLE identifies a population at higher risk of subsequent VE. |
| تدمد: | 1462-0332 1462-0324 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5deb0d818be4132a49d986e463ef9c5 https://doi.org/10.1093/rheumatology/keac596 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d5deb0d818be4132a49d986e463ef9c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14620332 14620324 |
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