Leishmania: manipulation of signaling pathways to inhibit host cell apoptosis
| العنوان: | Leishmania: manipulation of signaling pathways to inhibit host cell apoptosis |
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| المؤلفون: | Rosalino Vázquez-López, Diego Abelardo Álvarez-Hernández, Sandra-Georgina Solano-Gálvez, Laila Gutiérrez-Kobeh |
| المصدر: | Therapeutic Advances in Infectious Disease |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Programmed cell death, pathways, p38, Review, Biology, 03 medical and health sciences, 0302 clinical medicine, Pharmacology (medical), Fragmentation (cell biology), Protein kinase B, Neglected Tropical Diseases: Recent Progress and Future Challenges, Intracellular parasite, Akt, apoptosis, MAPK, inhibition, Cell biology, protozoan parasites, 030104 developmental biology, Infectious Diseases, Apoptosis, ERK 1/2, 030220 oncology & carcinogenesis, signaling PI3K, JNK, Signal transduction, Intracellular, Pyknosis |
| الوصف: | The maintenance of homeostasis in living systems requires the elimination of unwanted cells which is performed, among other mechanisms, by type I cell death or apoptosis. This type of programmed cell death involves several morphological changes such as cytoplasm shrinkage, chromatin condensation (pyknosis), nuclear fragmentation (karyorrhexis), and plasma membrane blebbing that culminate with the formation of apoptotic bodies. In addition to the maintenance of homeostasis, apoptosis also represents an important defense mechanism for cells against intracellular microorganisms. In counterpart, diverse intracellular pathogens have developed a wide array of strategies to evade apoptosis and persist inside cells. These strategies include the manipulation of signaling pathways involved in the inhibition of apoptosis where mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) play a key role. Leishmania is an intracellular protozoan parasite that causes a wide spectrum of diseases known as leishmaniasis. This parasite displays different strategies, including apoptosis inhibition, to down-regulate host cell defense mechanisms in order to perpetuate infection. |
| اللغة: | English |
| تدمد: | 2049-937X 2049-9361 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e74eaff2c16cb45d06de8aef4b1bf6 http://europepmc.org/articles/PMC8165860 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d5e74eaff2c16cb45d06de8aef4b1bf6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2049937X 20499361 |
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