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SARS-CoV-2 seroprevalence among health care workers in a New York City hospital: A cross-sectional analysis during the COVID-19 pandemic

التفاصيل البيبلوغرافية
العنوان: SARS-CoV-2 seroprevalence among health care workers in a New York City hospital: A cross-sectional analysis during the COVID-19 pandemic
المؤلفون: Vihren Dimitrov, Nehad Shabarek, Anjana Pillai, Sharika Menon, Moiz Kasubhai, Vidya Menon, Muhamed Abubacker, Muzamil Jawed, Nargis Jilani, Astrid Mendez Batres, Masood A. Shariff, Usha Venugopal, Sami Rabah
المصدر: International Journal of Infectious Diseases, Vol 102, Iss, Pp 63-69 (2021)
International Journal of Infectious Diseases
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Adult, Male, Cross-sectional study, Health Personnel, 030106 microbiology, Seroprevalence, Logistic regression, Article, COVID-19 Serological Testing, Exposure, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Hospitals, Urban, Seroepidemiologic Studies, Environmental health, Health care, Pandemic, Medicine, Humans, lcsh:RC109-216, 030212 general & internal medicine, Seroconversion, Pandemics, Antibody, Health care workers, business.industry, SARS-CoV-2, COVID-19, Odds ratio, General Medicine, Middle Aged, SARS-CoV-2 PCR, Infectious Diseases, Cross-Sectional Studies, COVID-19 Nucleic Acid Testing, Public hospital, Female, New York City, business
الوصف: Highlights • SARS-CoV-2 seroprevalence was high compared to community in a cohort of health care workers at a single institution in the Bronx after the surge. • Symptomatic participants had a higher rate of seroconversion compared to those without symptoms. • Health care workers with anosmia and ageusia had increased odds of seroconversion in comparison to those without these symptoms. • It is likely that a combination of healthcare and community exposure contributed to the seroprevalence.
Background New York City (NYC) has endured the greatest burden of COVID-19 infections in the US. Health inequities in South Bronx predisposed this community to a greater number of infections cases, hospitalisations and mortality. Health Care Workers (HCWs) are at high-risk of exposure to the infection. This study aims to assess seroprevalence and associated characteristics of consenting HCWs from a NYC public hospital. Methods Cross sectional study including serum samples for qualitative SARS-CoV-2 antibody testing with nasopharyngeal swabs for SARS-CoV-2 PCR and completion of an online survey capturing demographics, COVID-19 symptoms during the preceding months on duty, details of healthcare and community exposure, and travel history were collected from consenting participants in May 2020. Participants’ risk of exposure to COVID-19 infection in hospital and in the community was defined based on CDC guidelines. Travel history to high-risk areas was also considered an additional risk. The Odds Ratio with bivariable and multivariable logistic regression was used to assess characteristics associated with seroprevalence. Results A total of 500 HCW were tested, 137 (27%) tested positive for SARS-CoV-2 antibody. Symptomatic participants had a 75% rate of seroconversion compared to those without symptoms. Subjects with anosmia and ageusia had increased odds of seroconversion in comparison to those without these symptoms. Community exposure was 34% among those who had positive antibodies. Conclusion Seroprevalence among HCWs was high compared to the community at the epicenter of the pandemic. Further studies to evaluate sustained adaptive immunity in this high-risk group will guide our response to a future surge.
اللغة: English
تدمد: 1201-9712
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f1d872f15d8ce8eb76cee92d721670
http://www.sciencedirect.com/science/article/pii/S1201971220322402
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....d5f1d872f15d8ce8eb76cee92d721670
قاعدة البيانات: OpenAIRE
الوصف
تدمد:12019712