Rakicidin A: A Hypoxia-Selective Cytotoxin
| العنوان: | Rakicidin A: A Hypoxia-Selective Cytotoxin |
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| المؤلفون: | Setsuko Kunimoto, Daishiro Ikeda, Yohko Yamazaki |
| المصدر: | Biological and Pharmaceutical Bulletin. 30:261-265 |
| بيانات النشر: | Pharmaceutical Society of Japan, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Cell Survival, medicine.medical_treatment, Pharmaceutical Science, Antineoplastic Agents, CHO Cells, Peptides, Cyclic, Antioxidants, Lipopeptides, Cricetulus, Cell Line, Tumor, Cricetinae, medicine, Animals, Humans, Neoplasm, Cytotoxic T cell, Hypoxia, Cytotoxicity, Cell Proliferation, Pharmacology, Chemotherapy, biology, Chinese hamster ovary cell, General Medicine, Hypoxia (medical), medicine.disease, biology.organism_classification, Drug Resistance, Neoplasm, Cell culture, Immunology, Cancer research, medicine.symptom |
| الوصف: | Hypoxia is a common feature of many solid tumors and contributes to their progression. Hypoxic cells in the tumor are not only involved in therapeutic resistance to chemotherapy and radiotherapy but are also relevant to tumor angiogenesis. To identify novel hypoxia-selective cytotoxins, we screened 20000 cultured broths of microorganisms and found that rakicidin A showed significant hypoxia-selective cytotoxicity. Rakicidin A was approximately 17.5-fold more cytotoxic under hypoxic than under normoxic conditions. CoCl2 and antioxidants had no effect on the rakicidin A cytotoxicity under normoxic conditions and rakicidin A did not show the inhibitory effects on HIF-1 transcriptional activity under hypoxic conditions. Thus, although the action mechanism of the hypoxia-selective cytotoxicity of rakicidin A was unknown, our screening study suggested that rakicidin A acts as an antitumor agent for selective therapy against solid tumors. |
| تدمد: | 1347-5215 0918-6158 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61682b676c7f5b097069a27676da0f6 https://doi.org/10.1248/bpb.30.261 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d61682b676c7f5b097069a27676da0f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475215 09186158 |
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