Activation response and functional connectivity change in rat cortex after bilateral transcranial direct current stimulation—An exploratory study
| العنوان: | Activation response and functional connectivity change in rat cortex after bilateral transcranial direct current stimulation—An exploratory study |
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| المؤلفون: | Dirk Jan Ardesch, Caroline L. van Heijningen, Willem M. Otte, Annette van der Toorn, Milou Straathof, Gerard van Vliet, Julia Boonzaier, Rick M. Dijkhuizen |
| المساهمون: | Adult Psychiatry, Complex Trait Genetics, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Complex Trait Genetics |
| المصدر: | Boonzaier, J, Straathof, M, Ardesch, D J, van der Toorn, A, van Vliet, G, van Heijningen, C L, Otte, W M & Dijkhuizen, R M 2021, ' Activation response and functional connectivity change in rat cortex after bilateral transcranial direct current stimulation—An exploratory study ', Journal of Neuroscience Research, vol. 99, no. 5, pp. 1377-1389 . https://doi.org/10.1002/jnr.24793 Journal of neuroscience research, 99(5), 1377-1389. Wiley-Liss Inc. Journal of Neuroscience Research, 99(5), 1377-1389. Wiley-Liss Inc. Journal of Neuroscience Research |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Cerebral Cortex/physiology, medicine.medical_treatment, resting-state functional connectivity, Stimulation, Magnetic Resonance Imaging/methods, Rats, Sprague-Dawley, Sensorimotor Cortex/blood supply, 03 medical and health sciences, Cellular and Molecular Neuroscience, models, 0302 clinical medicine, SDG 3 - Good Health and Well-being, medicine, Premovement neuronal activity, Animals, magnetic resonance imaging, animal, Research Articles, Transcranial Direct Current Stimulation/methods, Cerebral Cortex, Transcranial direct-current stimulation, medicine.diagnostic_test, business.industry, Nerve Net/blood supply, resting‐state functional connectivity, Magnetic resonance imaging, Neuromodulation (medicine), Rats, 030104 developmental biology, Cerebral blood flow, Brain stimulation, Sensorimotor Cortex, Sprague-Dawley, Nerve Net, transcranial direct current stimulation, Motor learning, business, Neuroscience, 030217 neurology & neurosurgery, Research Article |
| الوصف: | Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique implicated as a promising adjunct therapy to improve motor function through the neuromodulation of brain networks. Particularly bilateral tDCS, which affects both hemispheres, may yield stronger effects on motor learning than unilateral stimulation. Therefore, the aim of this exploratory study was to develop an experimental model for simultaneous magnetic resonance imaging (MRI) and bilateral tDCS in rats, to measure instant and resultant effects of tDCS on network activity and connectivity. Naïve, male Sprague‐Dawley rats were divided into a tDCS (n = 7) and sham stimulation group (n = 6). Functional MRI data were collected during concurrent bilateral tDCS over the sensorimotor cortex, while resting‐state functional MRI and perfusion MRI were acquired directly before and after stimulation. Bilateral tDCS induced a hemodynamic activation response, reflected by a bilateral increase in blood oxygenation level‐dependent signal in different cortical areas, including the sensorimotor regions. Resting‐state functional connectivity within the cortical sensorimotor network decreased after a first stimulation session but increased after a second session, suggesting an interaction between multiple tDCS sessions. Perfusion MRI revealed no significant changes in cerebral blood flow after tDCS. Our exploratory study demonstrates successful application of an MRI‐compatible bilateral tDCS setup in an animal model. Our results indicate that bilateral tDCS can locally modulate neuronal activity and connectivity, which may underlie its therapeutic potential. Our study demonstrates that simultaneous functional magnetic resonance imaging (MRI) and transcranial direct current stimulation (tDCS) in rats is feasible with an MRI‐compatible electrode montage. We found that bilateral tDCS can locally modulate neural activity and functional connectivity in rat brain, while cortical functional connectivity is differentially affected under the tDCS cathode and anode. |
| اللغة: | English |
| تدمد: | 0360-4012 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d628d0e90003d887f340eb8feb0159d8 https://hdl.handle.net/1871.1/3fa3fd19-b105-4cf8-9c3a-5233823a85bc |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d628d0e90003d887f340eb8feb0159d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03604012 |
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