Relationship between Gd-IgA1 and TNFR1 in IgA nephropathy and IgA vasculitis nephritis in children - multicenter study
| العنوان: | Relationship between Gd-IgA1 and TNFR1 in IgA nephropathy and IgA vasculitis nephritis in children - multicenter study |
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| المؤلفون: | Jadwiga Małdyk, Beata Bieniaś, Małgorzata Pańczyk-Tomaszewska, Agnieszka Pukajło-Marczyk, Monika Pawlak-Bratkowska, Agnieszka Firszt-Adamczyk, Maria Szczepańska, Roman Stankiewicz, Agata Siejko, Przemysław Sikora, Magdalena Drożyńska-Duklas, Anna Stelmaszczyk-Emmel, Marcin Tkaczyk, Łukasz Gajewski, Danuta Zwolińska, Aleksandra Żurowska, Jacek Zachwieja, Małgorzata Mizerska-Wasiak, Anna Spława-Neyman, Karolina Cichoń-Kawa |
| المصدر: | Central-European Journal of Immunology Central European Journal of Immunology, Vol 46, Iss 2, Pp 199-209 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Immunology, Renal function, Urine, urologic and male genital diseases, Gastroenterology, Nephropathy, chemistry.chemical_compound, fluids and secretions, stomatognathic system, Internal medicine, henoch-schönlein nephritis, medicine, Immunology and Allergy, Gd-IgA1, Kidney, Creatinine, Proteinuria, business.industry, IgA vasculitis nephritis, Henoch-Schönlein nephritis, IgA nephropathy, medicine.disease, TNFR1, IgA vasculitis, medicine.anatomical_structure, chemistry, Medicine, Clinical Immunology, medicine.symptom, business, Nephritis |
| الوصف: | Aim of the study To evaluate the relationship between serum Gd-IgA1 (sGd-IgA1) and serum and urine TNFR1 (sTNFR1, uTNFR1) levels as possible prognostic factors in IgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN). Material and methods From 299 patients from the Polish Registry of Pediatric IgAN and IgAVN, 60 children (24 IgAN and 36 IgAVN) were included in the study. The control group consisted of 20 healthy children. Proteinuria, haematuria, serum creatinine as well as IgA and C3 levels were measured and glomerular filtration rate (GFR) was calculated at onset and at the end of the follow-up. Kidney biopsy findings were evaluated using the Oxford classification. Serum Gd-IgA1 and serum and urine TNFR1 levels were measured at the end of follow-up. Results Serum Gd-IgA1 level was significantly higher in IgAN and IgAVN patients in comparison to the control group. Urine TNFR1 was significantly higher in IgAN than in IgAVN and the control group. We did not observe any differences in sTNFR1 level between IgAN, IgAVN and control groups. We found a positive correlation between Gd-IgA1 and creatinine (r = 0.34), and negative between Gd-IgA1 and GFR (r = -0.35) at the end of follow-up. We observed a negative correlation between uTNFR1/creatinine log and albumin level and protein/creatinine ratio. We did not find any correlations between Gd-IgA1 and TNFR1. Conclusions The prognostic value of sGd-IgA1 in children with IgAN and IgAVN has been confirmed. TNFR1 is not associated with Gd-IgA1 and is not a useful prognostic marker in children with IgAN/IgAVN and normal kidney function. |
| تدمد: | 1426-3912 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6307c9b9b6fc6989db9b79b421c91b0 https://pubmed.ncbi.nlm.nih.gov/34764788 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d6307c9b9b6fc6989db9b79b421c91b0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14263912 |
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