Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer
| العنوان: | Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer |
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| المؤلفون: | Ng, EKO, Leung, WK, Sung, JJY, Chan, FKL, Liu, X, Wong, YP, Yu, J, Siu, JMT, Cheng, YY, Jin, H |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, Aza Compounds, Cancer Research, gastric cancer, digestive, oral, and skin physiology, Calcium-Binding Proteins, Down-Regulation, Genetics and Genomics, DNA Methylation, tumour suppressor gene, FBLN1, digestive system diseases, Up-Regulation, Gene Expression Regulation, Neoplastic, Oncology, Stomach Neoplasms, Cell Line, Tumor, Humans, Female, methylation, Promoter Regions, Genetic, Aged, Cell Proliferation |
| الوصف: | Tumour suppressor genes (TSGs) were frequently inactivated through promoter hypermethylation in gastric carcinoma as well as pre-malignant gastric lesions, suggesting that promoter hypermethylation can be used as a marker to define novel TSGs and also biomarkers for early detection of gastric cancer. In an effort to search for such genes aberrantly methylated in gastric cancer development, fibulin 1 (FBLN1) was found as a candidate TSG epigenetically downregulated in gastric cancer. FBLN1 expression was downregulated in all of gastric cancer cell lines used (100%, 7 out of 7) and the primary gastric carcinoma tissues (84%, 86 out of 102) and significantly restored after pharmacological demethylation. Hypermethylation of the FBLN1 promoter was frequently (71%, 5 out of 7) detected in gastric cancer cell lines and primary gastric carcinoma tissues. Ectopic expression of FBLN1 led to the growth inhibition of gastric cancer cells through the induction of apoptosis. In summary, FBLN1 was identified as a novel candidate TSG epigenetically downregulated in gastric cancer. © 2008 Cancer Research. published_or_final_version |
| تدمد: | 1532-1827 0007-0920 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d638674b829f4669652a75b888961a04 https://doi.org/10.1038/sj.bjc.6604760 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d638674b829f4669652a75b888961a04 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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