أعرض في EDS

Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract

التفاصيل البيبلوغرافية
العنوان: Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract
المؤلفون: Roos, E, Soer, E C, Klompmaker, S, Meijer, Laura, Besselink, M G, Giovannetti, E, Heger, M, Kazemier, G, Klümpen, H J, Takkenberg, R B, Wilmink, H, Würdinger, T, Dijk, F, van Gulik, T M, Verheij, J, van de Vijver, M J, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics
المساهمون: Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics
المصدر: Critical Reviews in Oncology/Hematology, 140, 8. Elsevier Ireland Ltd.
Roos, E, Soer, E C, Klompmaker, S, Meijer, L L, Besselink, M G, Giovannetti, E, Heger, M, Kazemier, G, Klümpen, H J, Takkenberg, R B, Wilmink, H, Würdinger, T, Dijk, F, van Gulik, T M, Verheij, J & van de Vijver, M J 2019, ' Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract ', Critical Reviews in Oncology/Hematology, vol. 140, pp. 8-16 . https://doi.org/10.1016/j.critrevonc.2019.05.011
سنة النشر: 2019
مصطلحات موضوعية: 0301 basic medicine, Phosphofructokinase-2/genetics, Biliary Tract Neoplasms/genetics, Chromogranins/genetics, Phosphofructokinase-2, Cell of origin, Isocitrate Dehydrogenase/genetics, Phosphoric Monoester Hydrolases/genetics, Receptor, Transforming Growth Factor-beta Type II/genetics, Cholangiocarcinoma, 0302 clinical medicine, Neoplasm Proteins/genetics, GTP-Binding Protein alpha Subunits, Gs, Medicine, biology, Hematology, GTP-Binding Protein alpha Subunits, Isocitrate Dehydrogenase, Neoplasm Proteins, medicine.anatomical_structure, Biliary Tract Neoplasms, Oncology, Biliary tract, 030220 oncology & carcinogenesis, Cholangiocarcinoma/genetics, Receptor, GTP-Binding Protein alpha Subunits, Gs/genetics, IDH1, Adenomatous Polyposis Coli Protein, Genomics, IDH2, Transforming Growth Factor-beta Type II/genetics, 03 medical and health sciences, GNAS complex locus, Chromogranins, Humans, Adenomatous Polyposis Coli Protein/genetics, Membrane Proteins/genetics, Gene, business.industry, Gallbladder, Receptor, Transforming Growth Factor-beta Type II, Membrane Proteins, Phosphoric Monoester Hydrolases, Gs/genetics, 030104 developmental biology, Mutation, Cancer research, biology.protein, business
الوصف: Biliary tract carcinoma (BTC) comprises gallbladder and intra-/extrahepatic cholangiocarcinoma (GBC, ICC, EHC), which are currently classified by anatomical origin. Better understanding of the mutational profile of BTCs might refine classification and improve treatment. We performed a systematic review of studies reporting on mutational profiling of BTC. We included articles reporting on whole-exome/whole-genome-sequencing (WES/WGS) and targeted sequencing (TS) of BTC, published between 2000-2017. Pooled mutation proportions were calculated, stratified by anatomical region and sequencing technique. A total of 25 studies with 1806 patients were included. Overall, TP53 was the most commonly mutated gene in BTC. GBC was associated with mutations in PFKFB3, PLXN2 and PGAP1. Mutations in IDH1, IDH2 and FGFR fusions almost exclusively occurred in ICC patients. Mutations in APC, GNAS and TGFBR2 occurred exclusively in EHC patients. In conclusion, subtypes of BTCs exhibit minor differences in mutational profile, which is likely influenced by the cell of origin.
وصف الملف: application/pdf
تدمد: 1879-0461
2000-2017
1040-8428
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64563fc2213fbeca1732853fe1f43b9
https://pubmed.ncbi.nlm.nih.gov/31158800
حقوق: RESTRICTED
رقم الأكسشن: edsair.doi.dedup.....d64563fc2213fbeca1732853fe1f43b9
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18790461
20002017
10408428