Growth During and 2 Years After Stopping GH Treatment in Prepubertal Children with Idiopathic Short Stature
| العنوان: | Growth During and 2 Years After Stopping GH Treatment in Prepubertal Children with Idiopathic Short Stature |
|---|---|
| المؤلفون: | S. Anin, Pearl Lilos, B. Klinger, Zvi Laron, Athalia Pertzelan |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism. 10 |
| بيانات النشر: | Walter de Gruyter GmbH, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Growth, School entry, Growth velocity, Endocrinology, Age Determination by Skeleton, medicine, Humans, Child, Human Growth Hormone, business.industry, Human growth hormone, Puberty, Mean age, Bone age, medicine.disease, Body Height, Idiopathic short stature, Physical performance, Pediatrics, Perinatology and Child Health, Gh treatment, Female, business |
| الوصف: | Forty-six prepubertal children with idiopathic short stature (ISS), 39 boys and 7 girls, with a mean age of 7.4 +/- 1.8 (SD) years, and mean bone age of 4.5 +/- 1.5 years were treated by human growth hormone (GH) 0.1 U/kg/day s.c. for 30.5 +/- 16.2 months (M +/- SD) (2-5 years range) and were followed for 1-2 years after stopping GH. The mean net gain in height at the end of treatment was 1.03 +/- 0.6 SDS and the bone age SDS was accelerated by 0.95 +/- 1.05. Despite a transitory "catch-down" in growth velocity after stopping GH administration, there was a mean height gain at the end of 2 years follow-up of 0.87 SDS. Children who started treatment before age 6.5 benefited more than older ones. In conclusion, the gain in height observed in children with ISS by GH treatment was maintained during 2 years of follow-up after interruption of treatment. Even if this benefit is transitory and not permanent, it may help short children to achieve self-confidence and raise their physical performance at the critical period of school entry. |
| تدمد: | 2191-0251 0334-018X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6514ab5a4441ab80a6976dd30e00645 https://doi.org/10.1515/jpem.1997.10.2.191 |
| رقم الأكسشن: | edsair.doi.dedup.....d6514ab5a4441ab80a6976dd30e00645 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910251 0334018X |
|---|