| الوصف: |
Ricong Xu,1,2 Zhijian Li,3,4 Tao Cao,1,2 Yi Xu,1,2 Ying Liao,1,2 Haiying Song,1,2 Xiaojie Chen,1,2 Fei Tang,1,2 Qiong Xiang,1,2 Qijun Wan1,2 1Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2The Second People’s Hospital of Shenzhen, Shenzhen, People’s Republic of China; 3Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 4Key Laboratory of Nephrology, National Health Commission and Guangdong Province, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Qijun WanDepartment of Nephrology, The First Affiliated Hospital of Shenzhen University, 3002 Sungang Road, Shenzhen, 518035, People’s Republic of ChinaTel +860755 83366388Email wanqj8964@163.comIntroduction: The Oxford Classification score, which predicts renal outcomes for immunoglobulin A nephropathy (IgAN), is widely used in clinical practice. Nevertheless, the relationship between these markers and longitudinal changes in renal function are poorly understood.Methods: This was a population-based retrospective cohort study of 280 adults with biopsy-proven primary IgAN from 2011 to 2018. We used generalized additive mixed models to control for traditional kidney disease risk factors to analyze the associations between Oxford Classification MEST-C scores (mesangial hypercellularity, M; endocapillary hypercellularity, E; segmental glomerulosclerosis, S; tubular atrophy/interstitial fibrosis, T; crescents, C) and longitudinal changes in the estimated glomerular filtration rate (eGFR) after renal biopsy.Results: The median eGFR was 78.2 mL/min/1.73 m2 at baseline, and then it decreased on average by 1.3 mL/min/1.73 m2 per year in the entire cohort. In adjusted models, compared with patients without relative lesions, the presence of T > 50% (T2) (− 5.7; 95% confidence interval [CI], − 9.5 to − 2.0 mL/min/1.73m2 per year) was associated with the fastest eGFR decline. S present (S1) (− 2.9; 95% CI, − 4.6 to − 1.1 mL/min/1.73m2 per year) and C > 25% glomeruli (C2) (− 3.4; 95% CI, − 6.4 to − 0.5 mL/min/1.73m2 per year) also demonstrated steeper eGFR declines. However, we found no association between M > 0.5 (M1), E present (E1), T 26%– 50% (T1), and C present ≥ 1 glomerulus (C1), and progressive eGFR decline (p > 0.05).Conclusion: The Oxford Classification scores, S1, T2, and C2, were independently associated with the longitudinal decreases in renal function in patients with IgAN. These findings suggested therapies targeted at improving early damage to these lesions might be essential to delay renal progression.Keywords: IgA nephropathy, Oxford Classification, renal function decline, a mixed-method study |
PDF full text from Publisher