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The relationship between inflammation and neoangiogenesis of epicardial adipose tissue and coronary atherosclerosis based on computed tomography analysis

التفاصيل البيبلوغرافية
العنوان: The relationship between inflammation and neoangiogenesis of epicardial adipose tissue and coronary atherosclerosis based on computed tomography analysis
المؤلفون: Toshiro Kitagawa, Atsuhiro Senoo, Hiroshi Tsushima, Yasuki Kihara, Kazuhiro Sentani, Shinya Takahashi, Wataru Yasui, Hideya Yamamoto, Taijiro Sueda
المصدر: Atherosclerosis. 243:293-299
بيانات النشر: Elsevier BV, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Male, medicine.medical_specialty, Antigens, Differentiation, Myelomonocytic, Adipose tissue, Inflammation, Coronary Artery Disease, Intra-Abdominal Fat, Coronary Angiography, Cohort Studies, Coronary artery disease, Antigens, CD, Internal medicine, medicine, Humans, Coronary Artery Bypass, Coronary atherosclerosis, Aged, Observer Variation, Neovascularization, Pathologic, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Coronary Vessels, Immunohistochemistry, Cardiac surgery, Coronary Calcium Score, Platelet Endothelial Cell Adhesion Molecule-1, medicine.anatomical_structure, Adipose Tissue, Angiography, Disease Progression, Cardiology, Female, Radiology, medicine.symptom, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Artery
الوصف: Previous studies indicate that epicardial adipose tissue (EAT) biologically contributes to the progression of coronary atherosclerosis. We evaluated the relationship between EAT pathology, represented by inflammation and neoangiogenesis, and coronary atherosclerosis on computed tomography (CT) images.We performed CT examination in 45 patients scheduled for cardiac surgery (coronary artery bypass graft [CABG], n = 21; non-CABG, n = 24) to assess visceral adipose tissue (VAT) area, EAT volume, coronary calcium score (CCS), and presence of non-calcified coronary plaque (NCP) on CT angiography. Each patient was assessed with the numbers of CD68(+) individual macrophages and CD31(+) neovessels in six random high-power fields (400×) of EAT samples subsequently obtained during cardiac surgery.In three groups based on CCS (mild, 0-100; moderate, 101-400; severe,400), the moderate group had the most extensive macrophage infiltration (p = 0.0025) and neoangiogenesis (p = 0.0036) in EAT. The patients with NCP had more extensive macrophage infiltration (p = 0.010) and neoangiogenesis (p = 0.0043) in EAT than those without. On multivariate analysis adjusted for age, sex, CABG versus. non-CABG, VAT area, and EAT volume, moderate CCS and the presence of NCP showed significant correlations with increased macrophage infiltration (β = 0.65; p0.0001, and β = 0.49; p = 0.0089, respectively) and neoangiogenesis (β = 0.55; p = 0.0011, and β = 0.53; p = 0.012, respectively) in EAT.Inflammation and neoangiogenesis in EAT independently correlate with moderate coronary calcification and presence of NCP, suggesting that these two factors may have a role in promoting coronary atherosclerosis.
تدمد: 0021-9150
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c490ae0365dc172f06a0e4858367f0
https://doi.org/10.1016/j.atherosclerosis.2015.09.013
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....d6c490ae0365dc172f06a0e4858367f0
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00219150