Spatiotemporal regulation of the anaphase-promoting complex in mitosis
| العنوان: | Spatiotemporal regulation of the anaphase-promoting complex in mitosis |
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| المؤلفون: | Gary J. Gorbsky, Sushama Sivakumar |
| المصدر: | Nature Reviews Molecular Cell Biology. 16:82-94 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Mitosis, Cell Cycle Proteins, Cell Biology, Polo-like kinase, Biology, Article, Anaphase-Promoting Complex-Cyclosome, APC/C activator protein CDH1, Cell biology, Mitotic cell cycle, Mitotic exit, Chromosome Segregation, Humans, Biochemical switches in the cell cycle, Anaphase-promoting complex, Molecular Biology, Cytokinesis, Anaphase |
| الوصف: | The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis. Key mitotic regulators are controlled through ubiquitylation and proteasome-mediated degradation. The APC/C (anaphase-promoting complex; also known as the cyclosome) is an E3 ubiquitin ligase that has a crucial function in the regulation of the mitotic cell cycle, particularly at the onset of anaphase and during mitotic exit. Co-activator proteins, inhibitor proteins, protein kinases and phosphatases interact with the APC/C to temporally and spatially control its activity and thus ensure accurate timing of mitotic events. |
| تدمد: | 1471-0080 1471-0072 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c9b65fdee0e0da4dd42950fd7d7ed6 https://doi.org/10.1038/nrm3934 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d6c9b65fdee0e0da4dd42950fd7d7ed6 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14710080 14710072 |
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