Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
| العنوان: | Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome |
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| المؤلفون: | Anca Sima, Jamila Fruchart-Najib, Jean-Charles Fruchart, Loredan S. Niculescu |
| المصدر: | Clinical Chemical Laboratory Medicine. 45 |
| بيانات النشر: | Walter de Gruyter GmbH, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | medicine.medical_specialty, Apolipoprotein B, Clinical Biochemistry, chemistry.chemical_compound, Gene Frequency, Risk Factors, Internal medicine, medicine, Humans, Insulin, Obesity, Allele, Allele frequency, Alleles, Apolipoproteins A, Triglycerides, Metabolic Syndrome, Polymorphism, Genetic, biology, Cholesterol, Homozygote, Biochemistry (medical), Genetic Variation, General Medicine, Atherosclerosis, medicine.disease, Minor allele frequency, Endocrinology, chemistry, Apolipoprotein A-V, Cardiovascular Diseases, Multigene Family, biology.protein, Gene polymorphism, Metabolic syndrome |
| الوصف: | Background: Genetic variation at the apolipoprotein A-V locus, recently discovered proximal to the APOA1/C3/A4 gene cluster, is associated with elevated triglyceride concentrations, a risk factor for atherosclerosis. Methods: The goal of our study was to determine the association of two apolipoprotein A-V (APOA5) gene polymorphisms in a group of urban Romanian subjects with the prevalence of the metabolic syndrome. For this purpose, we assayed -1.131T>C and c.56C>G polymorphisms for 279 subjects divided into three groups: a control group, a metabolic syndrome group and a cardiovascular disease group. Then we correlated the minor allele frequencies with body mass index and biochemical parameters. Results: We obtained higher frequency for - 1.131C compared to c.56G alleles, both mainly distributed in overweight subjects. Body mass index and triglyceride levels were higher in -1.131C allele carriers in metabolic syndrome patients, but were not significantly different in c.56G carriers compared to those with the native gene. Metabolic syndrome -1.131C homozygotes presented lower high-density lipoprotein cholesterol and higher glucose levels compared to subjects with the native gene. Total cholesterol, low-density lipoprotein cholesterol and insulin were not different between - 1.131C or C.56G allele carriers and those with the native gene. Conclusions: Our results demonstrate an independent risk for -1.131T>C APOA5 gene polymorphisms in the development of metabolic syndrome. |
| تدمد: | 1437-4331 1434-6621 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fae7132158f6a344e42eb7dad37292 https://doi.org/10.1515/cclm.2007.257 |
| رقم الأكسشن: | edsair.doi.dedup.....d6fae7132158f6a344e42eb7dad37292 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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