Determinants of outcomes for acute encephalopathy with reduced subcortical diffusion
| العنوان: | Determinants of outcomes for acute encephalopathy with reduced subcortical diffusion |
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| المؤلفون: | Yukihiro Akita, Keizo Ohbu, Takaoki Yokochi, Toyojiro Matsuishi, Toru Imagi, Masao Suda, Go Kawano, Yukako Yae, Kensuke Sakata |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Encephalopathy, Thalamus, Population, lcsh:Medicine, Paediatric research, Article, Basal Ganglia, White matter, 03 medical and health sciences, 0302 clinical medicine, Hypothermia, Induced, Seizures, 030225 pediatrics, Internal medicine, Basal ganglia, medicine, Humans, Effective diffusion coefficient, lcsh:Science, education, Retrospective Studies, education.field_of_study, Multidisciplinary, business.industry, lcsh:R, Infant, Retrospective cohort study, Hypothermia, medicine.disease, Diffusion Magnetic Resonance Imaging, Treatment Outcome, medicine.anatomical_structure, Child, Preschool, Multivariate Analysis, Cardiology, lcsh:Q, Female, medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | Acute encephalopathy with reduced subcortical diffusion (AED), characterised by seizure onset and widespread reduced apparent diffusion coefficient in the cortex/subcortical white matter, is one of the most common acute encephalopathies in children in East Asia. This 14-year single-centre retrospective study on 34 patients with AED showed that therapeutic hypothermia was used for patients with more severe consciousness disturbance after the first seizure or second phase initiation, extrapolating from neonatal hypoxic encephalopathy and adult post-cardiac arrest syndrome. The basal ganglia/thalamus lesions and the Tada score were the poor outcome determinants in the multivariate analysis. The correlation between the worse outcomes and the duration from the first seizure to the initiation of therapeutic hypothermia was observed only in the patients with AED cooled before the second phase. This correlation was not observed in the overall AED population. There was a moderate negative association between the worse outcomes and the duration between the first seizure and the second phase. Therefore, the basal ganglia/thalamus lesions and the Tada score were the outcome determinants for patients with AED. Further investigation is required to examine the efficacy of therapeutic hypothermia in this population while considering the timing of the therapeutic hypothermia initiation and the second phase. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7110046415c460e5498fc5212c7a493 https://doi.org/10.1038/s41598-020-66167-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d7110046415c460e5498fc5212c7a493 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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