EGF-liposomes promote efficient EGFR targeting in xenograft colocarcinoma model
| العنوان: | EGF-liposomes promote efficient EGFR targeting in xenograft colocarcinoma model |
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| المؤلفون: | Gerben A. Koning, Iñaki F. Trocóniz, Iñigo Navarro, María J. Garrido, María Merino, Conchita Tros de Ilarduya, Sara Zalba, Ana Margarita Contreras |
| المساهمون: | Surgery |
| المصدر: | Nanomedicine, 11(5), 465-477. Future Medicine Ltd. |
| بيانات النشر: | Future Medicine Ltd, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Organoplatinum Compounds, medicine.drug_class, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, Spleen, 02 engineering and technology, Development, Pharmacology, Monoclonal antibody, Mice, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Epidermal growth factor, Cell Line, Tumor, medicine, Animals, Humans, General Materials Science, Molecular Targeted Therapy, IC50, Liposome, Epidermal Growth Factor, Cetuximab, business.industry, 021001 nanoscience & nanotechnology, Xenograft Model Antitumor Assays, In vitro, Oxaliplatin, ErbB Receptors, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Liposomes, Colorectal Neoplasms, 0210 nano-technology, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug |
| الوصف: | Aim: Development of EGF-liposomes (LP-EGF) for selective molecules delivery in tumors expressing EGFR. Material & methods: In vitro cellular interaction of EGF-LP and nontargeted liposomes (LP-N) was assayed at 37 and 4°C in cells expressing different EGFR levels. Receptor-mediated uptake was investigated by competition with a monoclonal antibody anti-EGFR. Selective intracellular drug delivery and efficacy was tested by oxaliplatin encapsulation. In vivo biodistribution of LP-N and LP-EGF was done in xenograft model. Results: LP-EGF was internalized by an active and selective mechanism through EGFR without receptor activation. Oxaliplatin LP-EGF decreased IC50 between 48 and 13% in cell EGFR+. LP-EGF was accumulated in tumor over 72 h postdosing, while LP-N in spleen. Conclusion: LP-EGF represents an attractive nanosystem for cancer therapy or diagnosis. |
| تدمد: | 1748-6963 1743-5889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72ff96a4e26d5c2553d230a425a3204 https://doi.org/10.2217/nnm.15.208 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....d72ff96a4e26d5c2553d230a425a3204 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17486963 17435889 |
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