التفاصيل البيبلوغرافية
العنوان:
Age-, Site-, and Sex-Specific Normative Centile Curves for HR-pQCT-Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population
المؤلفون:
Ruizhi Jiajue , Yan Jiang , Ou Wang , Fan Yu , Ling Qin , Weibo Xia , Xiaoping Xing , Yuping Xu , Yanfang Hou , Yuanyuan Lin , Li Zhang , Evelyn Hsieh , Mei Li
المصدر:
J Bone Miner Res
سنة النشر:
2019
مصطلحات موضوعية:
0301 basic medicine , Male , Percentile , China , Endocrinology, Diabetes and Metabolism , Osteoporosis , Population , 030209 endocrinology & metabolism , Bone and Bones , Article , 03 medical and health sciences , 0302 clinical medicine , Bone Density , Medicine , Humans , Orthopedics and Sports Medicine , Tibia , Quantitative computed tomography , education , Bone mineral , education.field_of_study , medicine.diagnostic_test , business.industry , medicine.disease , Radius , 030104 developmental biology , medicine.anatomical_structure , Normative , Cortical bone , Female , business , Switzerland , Demography
الوصف:
High-resolution peripheral quantitative computed tomography (HR-pQCT) is an advanced 3D imaging technology that has the potential to contribute to fracture risk assessment and early diagnosis of osteoporosis. However, to date no studies have sought to establish normative reference ranges for HR-pQCT measures among individuals from the Chinese mainland, significantly restricting its use. In this study, we collected HR-pQCT scans from 863 healthy Chinese men and women aged 20 to 80 years using the latest-generation scanner (Scanco XtremeCT II, Scanco Medical AG, Bruttisellen, Switzerland). Parameters including volumetric bone mineral density, bone geometry, bone microarchitecture, and bone strength were evaluated. Age-, site-, and sex-specific centile curves were established using generalized additive models for location, scale, and shape with age as the only explanatory variable. Based on established models, age-related variations for different parameters were also quantified. For clinical purposes, the expected values of HR-pQCT parameters for a defined age and a defined percentile or Z-score were provided. We found that the majority of trabecular and bone strength parameters reached their peak at 20 years of age, regardless of sex and site, then declined steadily thereafter. However, most of the cortical bone loss was observed after the age of 50 years. Among the measures, cortical porosity changed most dramatically, and overall, changes were more notable at the radius than the tibia and among women compared with men. Establishing such normative HR-pQCT reference data will provide an important basis for clinical and research applications in mainland China aimed at elucidating microstructural bone damage driven by different disease states or nutritional status. © 2020 American Society for Bone and Mineral Research.
تدمد:
1523-4681
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d730313e30d11d1850c18eddd062e23e https://pubmed.ncbi.nlm.nih.gov/32564403
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....d730313e30d11d1850c18eddd062e23e
قاعدة البيانات:
OpenAIRE
