Study on Solubilization and Stabilization of Eight Flavonoids by 17 Chinese Herbal Polysaccharides
| العنوان: | Study on Solubilization and Stabilization of Eight Flavonoids by 17 Chinese Herbal Polysaccharides |
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| المؤلفون: | Yanru Deng, Lei Wang, Xuexiao Cao, Tingting Han, Xiaoliang Ren, Meiqi Liu |
| المصدر: | Journal of Chemistry, Vol 2020 (2020) |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | chemistry.chemical_classification, 0303 health sciences, Chromatography, 010405 organic chemistry, fungi, food and beverages, General Chemistry, Buffer solution, Polysaccharide, 01 natural sciences, High-performance liquid chromatography, 0104 chemical sciences, Baicalein, Bioavailability, carbohydrates (lipids), 03 medical and health sciences, chemistry.chemical_compound, Chemistry, chemistry, Solubilization, heterocyclic compounds, Solubility, Quercetin, QD1-999, 030304 developmental biology |
| الوصف: | Flavonoids are important active components of traditional Chinese medicines (TCMs) because of their many biological activities. We studied the interaction between 17 polysaccharides and eight flavonoids via high-performance liquid chromatography (HPLC) and the effect of the interactions on the solubility and stability of the flavonoids. The effect of the polysaccharides on the solubility of flavonoids was analyzed by statistical methods and showed significant solubility improvements. The constant temperature acceleration method (90°C/pH 9 buffer solution) was used to measure the degradation kinetics and half-life of flavonoids with and without polysaccharides. All the polysaccharides displayed a stabilizing effect on all eight flavonoids. The stabilizing effects varied in the order: quercetin, baicalein > baicalin > galuteolin > daidzin > rutin > luteolin > daidzien. The phase-solubility method was applied to quercetin and baicalein to study the mechanism of action of the polysaccharides. It appeared that the two flavonoids could form 1 : 1 inclusion complexes with polysaccharides, which may be one of the factors increasing solubility and stability. These findings increase our understanding of the role of endogenous polysaccharides in TCM in improving the stability and bioavailability of bioactive flavonoids. |
| اللغة: | English |
| تدمد: | 2090-9071 2090-9063 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74a0b1bc5d977148f9732397a8a9d51 https://doaj.org/article/49016b65ed9440fbb808c3c00a296d92 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d74a0b1bc5d977148f9732397a8a9d51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20909071 20909063 |
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