Association of KMT2C/D loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer
| العنوان: | Association of KMT2C/D loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer |
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| المؤلفون: | Ruiqi Liu, Yanling Niu, Chao Liu, Xin Zhang, Jinku Zhang, Min Shi, Wenbo Zou, Binbin Gu, Honglin Zhu, Danhua Wang, Hongling Yuan, Wei Li, Dandan Zhao, Qiaosong Zheng, Rong Liu, Weiping Chen, Tonghui Ma, Yanqiao Zhang |
| المصدر: | Cancer Science. 114:1229-1239 |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cancer Research, Oncology, General Medicine |
| الوصف: | Immune checkpoint inhibitors (ICIs) have become important treatment strategies, yet responses vary among patients and predictive biomarkers are urgently needed. Mutations in KMT2C and KMT2D lead to increased levels of genomic instability. Therefore, we aimed to examine whether KMT2C/D mutations might be a predictor of immunotherapeutic efficacy. Herein, we investigated the associations of KMT2C/D loss-of-function (LOF) variants with TMB, MSI-H, PD-L1 expression, the levels of tumor-infiltrating leukocytes (TILs), and clinical response to ICIs. It was found that KMT2C/D LOF variants were associated with higher TMB. Compared to the non-LOF group, the proportion of patients with MSI-H tumors was larger in the LOF group. The PD-L1 expression was higher in the LOF group only for colorectal cancer in both the Chinese and TCGA cohorts. Importantly, KMT2C/D LOF variants were associated with decreased regulatory T cells and increased levels of CD8 |
| تدمد: | 1349-7006 1347-9032 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b015c4248f54c86f2489066797a044 https://doi.org/10.1111/cas.15716 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d7b015c4248f54c86f2489066797a044 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497006 13479032 |
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