Gut microbial signatures and differences in bipolar disorder and schizophrenia of emerging adulthood
| العنوان: | Gut microbial signatures and differences in bipolar disorder and schizophrenia of emerging adulthood |
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| المؤلفون: | Yi‐huan Chen, Cui‐hong Zhou, Huan Yu, Wen‐jun Wu, Ying‐wei Wang, Ling Liu, Guang‐tao Hu, Bao‐juan Li, Zheng‐wu Peng, Hua‐ning Wang |
| المصدر: | CNS Neuroscience & Therapeutics. |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, Psychiatry and Mental health, Physiology (medical), Pharmacology (medical) |
| الوصف: | Gut microbial disturbance has been established as potential pathogenesis of mental disorders. However, the signatures and differences regarding patients with schizophrenia (SCH) or bipolar disorder (BD) in emerging adulthood as well as their subtypes have been poorly addressed.In the present study, stool samples obtained from 63 emerging adult patients with schizophrenia (SCH), 50 with bipolar disorder (BD), and 40 healthy controls (HC) were analyzed by 16 S rRNA gene sequencing; psychiatric symptoms and psychological, social, and professional functioning were also assessed.We found that gut microbiota composition was remarkably changed in the patients with SCH and BD. Moreover, the distinct gut microbiome signatures and their potential function in bipolar depression (BP-D) and SCH with predominantly negative symptoms (SCH-N) as well as bipolar mania (BP-M) and SCH with predominantly positive symptoms (SCH-P) were also observed. Furthermore, we identified diagnostic potential biomarkers that can distinguish BD from HC (38 genera, AUC = 0.961), SCH from HC (32 genera, AUC = 0.962), and BD from Scheme (13 genera, AUC = 0.823). Potential diagnostic biomarkers that can distinguish BD-D from SCH-N (16 genera, AUC = 0.969) and BD-M from SCH-P (31 genera, AUC = 0.938) were also identified.This study provides further understanding of abnormal gut microbiome in emerging adulthood patients with SCH and BD and lay the potential foundation for the development of microbe-based clinical diagnosis for BD and SCH. |
| تدمد: | 1755-5949 1755-5930 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c3359109ccf446197cf8a6cb36e2ac https://doi.org/10.1111/cns.14044 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d7c3359109ccf446197cf8a6cb36e2ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17555949 17555930 |
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