Crosstalk between RNA m6A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
| العنوان: | Crosstalk between RNA m6A Modification and Non-coding RNA Contributes to Cancer Growth and Progression |
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| المؤلفون: | Zheng Xiwang, Changming An, Wei Gao, Linshi Zhang, Yan Lu, Dai Li, Xu Wei, Yongyan Wu, Yujia Guo, Dai Fengsheng, Huizheng Li |
| المصدر: | Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 62-71 (2020) Molecular Therapy. Nucleic Acids |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, non-coding RNA, Review, Biology, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Circular RNA, Drug Discovery, microRNA, medicine, cancer, Gene, long non-coding RNA, N6-methyladenosine, lcsh:RM1-950, RNA, circular RNA, Non-coding RNA, Long non-coding RNA, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, chemistry, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, N6-Methyladenosine, Carcinogenesis |
| الوصف: | N6-methyladenosine (m6A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m6A regulators can lead to an imbalance in m6A levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppressor genes that may contribute to cancer development, patient response to chemoradiotherapy, and clinical prognosis. Recent studies demonstrate that non-coding RNAs are involved in epigenetic modification of both DNA and RNA in tumor cells, and may also affect the development and progression of cancer by targeting m6A regulators. In this review, we describe the functional crosstalk between m6A and non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, and illustrate their roles in tumor regulation. Finally, we discuss the significance of non-coding RNA and m6A modification in the diagnosis, treatment, and prognosis of cancer patients, as well as potential future research directions. Graphical Abstract As a pivotal member of RNA modification, m6A plays an important role in the initiation and progression of cancer. However, the mechanism between m6A regulators and non-coding RNAs is largely unknown. Gao and colleagues summarize the crosstalk between m6A and non-coding RNAs in cancers and provide potential novel research directions. |
| اللغة: | English |
| تدمد: | 2162-2531 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c5b621320687a5a9380699eac5a243 http://www.sciencedirect.com/science/article/pii/S216225312030233X |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d7c5b621320687a5a9380699eac5a243 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21622531 |
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