Prognostic significance of endoscopic ultrasound-defined pleural, pericardial or peritoneal fluid in oesophageal cancer
| العنوان: | Prognostic significance of endoscopic ultrasound-defined pleural, pericardial or peritoneal fluid in oesophageal cancer |
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| المؤلفون: | Christopher P. Twine, Wyn G. Lewis, S. Ashley Roberts, Jonathan D. Barry, Guy Blackshaw, Tom Crosby |
| المصدر: | Surgical Endoscopy. 23:2229-2236 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Endoscopic ultrasound, medicine.medical_specialty, Esophageal Neoplasms, Pleural effusion, medicine.medical_treatment, Pericardial effusion, Pericardial Effusion, Statistics, Nonparametric, Endosonography, Pleural disease, Predictive Value of Tests, medicine, Ascitic Fluid, Humans, Pericardium, Survival rate, Neoadjuvant therapy, Aged, Neoplasm Staging, Proportional Hazards Models, Aged, 80 and over, medicine.diagnostic_test, business.industry, Middle Aged, Prognosis, medicine.disease, Pleural Effusion, Survival Rate, medicine.anatomical_structure, Pleurisy, Female, Surgery, Radiology, Tomography, X-Ray Computed, business |
| الوصف: | Endoscopic ultrasound (EUS) is known to detect smaller effusion volumes than computerised tomography (CT), yet the outcomes for patients diagnosed with oesophageal carcinoma and EUS-defined pleural, pericardial or ascitic fluid effusions (EDFE) are unknown. The aim of this study was to determine the outcome of multidisciplinary stage directed treatment for such patients. Forty-nine (9.2%) out of a consecutive 527 patients diagnosed with oesophageal cancer from a single regional upper gastrointestinal (GI) cancer network were found to have evidence of EDFE undetected by CT. Thirty-nine (79.6%) patients had pleural effusions, eight (16.3%) pericardial effusions, and two (4.1%) ascites. Twelve (24.4%) underwent surgery, 3 (6.1%) received neoadjuvant chemotherapy without subsequent surgery, 12 (24.5%) received definitive chemoradiotherapy (dCRT), and 22 (44.9%) received palliative treatment. Survival in patients with EDFE was significantly shorter (median and 2-year survival 15.6 months and 24%, respectively) when compared with patients without EDFE (26.7 months and 40%, respectively, p = 0.001), and was unrelated to EDFE type (p = 0.192). Two-year survival after oesophagectomy with or without neoadjuvant therapy was 45% in patients with EDFE compared with 42% in patients without EDFE (p = 0.668). EDFE was an important adverse prognostic indicator, but patients deemed to have operable tumours should still be treated with radical intent. |
| تدمد: | 1432-2218 0930-2794 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fb637f42364abea6b5f3e62f6b1eb3 https://doi.org/10.1007/s00464-008-0286-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d7fb637f42364abea6b5f3e62f6b1eb3 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322218 09302794 |
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