An integrated formulation of anisotropic force-calcium relations driving spatio-temporal contractions of cardiac myocytes
| العنوان: | An integrated formulation of anisotropic force-calcium relations driving spatio-temporal contractions of cardiac myocytes |
|---|---|
| المؤلفون: | Philippe Tracqui, Jacques Ohayon |
| المساهمون: | DynaCell, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Dynacell |
| المصدر: | Philos Trans A Math Phys Eng Sci Philos Trans A Math Phys Eng Sci, 2009, 367 (1908), pp.4887-905. ⟨10.1098/rsta.2009.0149⟩ |
| بيانات النشر: | HAL CCSD, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Sarcomeres, MESH: Models, Cardiovascular, MESH: Myocardial Contraction, General Mathematics, Myogenic contraction, [SDV]Life Sciences [q-bio], Finite Element Analysis, General Physics and Astronomy, chemistry.chemical_element, MESH: Myocytes, Cardiac, Calcium, Calcium in biology, Contractility, 03 medical and health sciences, 0302 clinical medicine, MESH: Computer Simulation, Myocyte, Humans, Computer Simulation, Myocytes, Cardiac, 030304 developmental biology, 0303 health sciences, Microscopy, Video, MESH: Humans, MESH: Finite Element Analysis, MESH: Sarcomeres, Cardiac myocyte, General Engineering, Models, Cardiovascular, Myocardial Contraction, Calcium sparks, MESH: Microscopy, Video, chemistry, MESH: Calcium, Biophysics, MESH: Anisotropy, Anisotropy, 030217 neurology & neurosurgery, Intracellular |
| الوصف: | International audience; Isolated cardiac myocytes exhibit spontaneous patterns of rhythmic contraction, driven by intracellular calcium waves. In order to study the coupling between spatio-temporal calcium dynamics and cell contraction in large deformation regimes, a new strain-energy function, describing the influence of sarcomere length on the calcium-dependent generation of active intracellular stresses, is proposed. This strain-energy function includes anisotropic passive and active contributions that were first validated separately from experimental stress-strain curves and stress-sarcomere length curves, respectively. An extended validation of this formulation was then conducted by considering this strain-energy function as the core of an integrated mechano-chemical three-dimensional model of cardiac myocyte contraction, where autocatalytic intracellular calcium dynamics were described by a representative two-variable model able to generate realistic intracellular calcium waves similar to those observed experimentally. Finite-element simulations of the three-dimensional cell model, conducted for different intracellular locations of triggering calcium sparks, explained very satisfactorily, both qualitatively and quantitatively, the contraction patterns of cardiac myocytes observed by time-lapse videomicroscopy. This integrative approach of the mechano-chemical couplings driving cardiac myocyte contraction provides a comprehensive framework for analysing active stress regulation and associated mechano-transduction processes that contribute to the efficiency of cardiac cell contractility in both physiological and pathological contexts. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fb70cee368173cf59e7ec6ae37935d https://hal.archives-ouvertes.fr/hal-00846377 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d7fb70cee368173cf59e7ec6ae37935d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |