Estimation and Comparison of Salivary Secretory Leukocyte Protease Inhibitor in Human Immunodeficiency Virus Patients and Healthy Individuals
| العنوان: | Estimation and Comparison of Salivary Secretory Leukocyte Protease Inhibitor in Human Immunodeficiency Virus Patients and Healthy Individuals |
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| المؤلفون: | Kumar Pushpanshu, Rachna Kaushik, Ramhari S Sathawane |
| المصدر: | Indian Journal of Palliative Care Indian Journal of Palliative Care, Vol 20, Iss 1, Pp 26-30 (2014) |
| بيانات النشر: | Medknow Publications & Media Pvt Ltd, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Regulation of opioids, Saliva, effective factors, Resuscitation, Human immunodeficiency virus (HIV), Nurses, CD4 count, medicine.disease_cause, Virus, Do not resuscitate orders, medicine, Healthcare workers, Clinical significance, Protease inhibitor (pharmacology), nurse-patient communication, Advanced care directive, Cancer, lcsh:R5-920, Secretory leukocyte protease inhibitor, Transmission (medicine), business.industry, Human immunodeficiency virus, Health Policy, Palliative Care, Public Health, Environmental and Occupational Health, Thailand, Pain management, Knowledge, Oncology, Healthy individuals, Immunology, Perception, Original Article, business, End of life care, lcsh:Medicine (General), SLPI |
| الوصف: | Aim: Transmission of human immunodeficiency virus (HIV) in the oral cavity is a rare event, despite detectable virus in saliva and oropharyngeal tissues of infected persons, unlike other mucosal sites. Secretory leukocyte protease inhibitor (SLPI) has been suggested as the main soluble factor responsible for the HIV inhibitory effect of saliva. The study was designed to estimate and compare the salivary SLPI levels in HIV patients and healthy controls. Furthermore, the relationship between salivary SLPI levels and disease severity was also investigated. Materials and Methods: Unstimulated whole saliva specimens were collected from 60 HIV-infected and 20 healthy subjects. Disease severity was determined by CD4 count in HIV subjects, who were divided into two groups: ≥200 cells/μL (n = 30) and < 200 cells/μL n = 30. Salivary SLPI levels were determined by enzyme-linked immunosorbent assay. Results: Numerically higher SLPI levels were observed in HIV subjects 193.342 ng/mL vs. 190.587 ng/mL; P = 0.517. A nonsignificant negative correlation was noted between CD4 counts and SLPI levels r = −0.037, P = 0.781. Conclusion: The salivary anti-HIV factor, SLPI, is not only preserved in HIV infection but its concentration may even get enhanced in the infection. However, the clinical significance of SLPI levels and disease severity should be investigated further with a larger sample of patients. |
| اللغة: | English |
| تدمد: | 1998-3735 0973-1075 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81b97d2ae4a31d25bfdce11002005ee http://europepmc.org/articles/PMC3931238 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d81b97d2ae4a31d25bfdce11002005ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983735 09731075 |
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