Population pharmacokinetics of olprinone in patients undergoing cardiac surgery with cardiopulmonary bypass
| العنوان: | Population pharmacokinetics of olprinone in patients undergoing cardiac surgery with cardiopulmonary bypass |
|---|---|
| المؤلفون: | Ken Yamamoto, Tsunehisa Tsubokawa, Syuichi Ishizuka, Kazuyuki Ueno, Kyoko Fukumoto |
| المصدر: | Journal of Anesthesia. 27:243-250 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Inotrope, Cardiotonic Agents, Phosphodiesterase Inhibitors, Pyridones, Population, Renal function, law.invention, Pharmacokinetics, law, Olprinone, Cardiopulmonary bypass, Humans, Medicine, Computer Simulation, Cardiac Surgical Procedures, education, Chromatography, High Pressure Liquid, Aged, Whole blood, Volume of distribution, education.field_of_study, Cardiopulmonary Bypass, business.industry, Body Weight, Imidazoles, Middle Aged, Anesthesiology and Pain Medicine, Creatinine, Anesthesia, Female, business, Half-Life |
| الوصف: | Olprinone, a phosphodiesterase type III inhibitor, is a strong inotrope and vasodilator that does not increase oxygen consumption and is often used during weaning from cardiopulmonary bypass (CPB). To control the pharmacological effects of olprinone, pharmacokinetic information is essential; however, there is little published information on the pharmacokinetics of olprinone in a large population. Therefore, the purpose of this study was to determine olprinone pharmacokinetic parameters in a large population undergoing cardiac surgery with CPB. Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Whole blood samples were periodically obtained to determine the olprinone concentrations using high-performance liquid chromatography. Measured olprinone concentrations were analyzed with a one-compartment model via a population approach. A total of 86 blood samples from 26 patients were used for pharmacokinetic analysis. The calculated clearance, volume of distribution (V d), and elimination half-life were 378 ml/min, 40.7 l, and 97.1 min, respectively. Olprinone clearance depended on weight and creatinine clearance, whereas V d depended only on weight. We investigated the pharmacokinetic parameters of olprinone in patients undergoing cardiac surgery with CPB. Olprinone clearance depended on weight and creatinine clearance, whereas V d depended only on weight. When olprinone is infused according to the recommended dosing regimen, it takes more than 60 min to reach the target concentration (20 ng/ml). However, there is a possibility that a lower concentration is sufficient for weaning from CPB in combination with a continuous infusion of dopamine. |
| تدمد: | 1438-8359 0913-8668 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d822abd2d12528d43d1cedd33a951590 https://doi.org/10.1007/s00540-012-1505-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d822abd2d12528d43d1cedd33a951590 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14388359 09138668 |
|---|