The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3
| العنوان: | The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3 |
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| المؤلفون: | Muzaffar Ali, Jae-Woo Ahn, Wenyi Mi, Brianna J. Klein, Wei Li, Xiaobing Shi, Xiaolu Wang, Hong Wen, Yongming Xue, Yi Zhang, Tatiana G. Kutateladze, Jiejun Shi |
| المصدر: | Nature structural & molecular biology |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, PTM, Protein domain, p300, histone, Article, Cell Line, Histones, 03 medical and health sciences, Histone H3, chemistry.chemical_compound, Protein Domains, Structural Biology, bromodomain, p300-CBP Transcription Factors, ZZ domain, Molecular Biology, Nuclear Magnetic Resonance, Biomolecular, Histone Acetyltransferases, Zinc finger, biology, Chemistry, Acetylation, Zinc Fingers, 3. Good health, Bromodomain, Chromatin, Cell biology, 030104 developmental biology, Histone, Spectrometry, Fluorescence, Acetyllysine, HAT, biology.protein, chromatin |
| الوصف: | Human p300 is a transcriptional co-activator and a major acetyltransferase that acetylates histones and other proteins facilitating gene transcription. The activity of p300 relies on the fine-tuned interactome that involves a dozen p300 domains and hundreds of binding partners and links p300 to a wide range of vital signaling events. Here, we report a novel function of the ZZ-type zinc finger (ZZ) of p300 as a reader of histone H3. We show that the ZZ domain and acetyllysine-recognizing bromodomain of p300 play critical roles in modulating p300 enzymatic activity and its association with chromatin. The acetyllysine binding function of bromodomain is essential for acetylation of histones H3 and H4, whereas interaction of the ZZ domain with H3 promotes selective acetylation of the histone H3K27 and H3K18 sites. |
| اللغة: | English |
| تدمد: | 1545-9985 1545-9993 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82ded6390063dbf8decce17ef149577 http://europepmc.org/articles/PMC6482957 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d82ded6390063dbf8decce17ef149577 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15459985 15459993 |
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