Antibody Response of Restricted Isotype to Heat Shock Proteins in Juvenile Chronic Arthritis
| العنوان: | Antibody Response of Restricted Isotype to Heat Shock Proteins in Juvenile Chronic Arthritis |
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| المؤلفون: | H. Monaghan, E. M. Ó Nualláin, D. J. Reen |
| المصدر: | Scandinavian Journal of Immunology. 38:83-88 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Male, Adolescent, Chaperonins, T-Lymphocytes, Immunology, Peripheral blood mononuclear cell, Antibodies, Immunoglobulin G, Mycobacterium, Bacterial Proteins, Heat shock protein, Escherichia coli, medicine, Humans, Child, Heat-Shock Proteins, biology, Chaperonin 60, General Medicine, medicine.disease, Isotype, Arthritis, Juvenile, Immunoglobulin M, Child, Preschool, Humoral immunity, biology.protein, Female, Antibody, Juvenile rheumatoid arthritis |
| الوصف: | Synovial fluid and peripheral blood mononuclear cells from juvenile chronic arthritis (JCA) patients have previously been shown to exhibit substantial proliferative responses to both human and mycobacterial heat shock protein (hsp) 65. We investigated the nature of the antibody response to mycobacterial and E. coli hsp 65 and human and E. coli hsp 70 in 56 JCA patients using an ELISA. Elevated levels of antibodies to both human and E. coli hsp 70 were demonstrated. With hsp 65, raised levels of antibodies to the mycobacterial but not the E. coli protein were detected. Overall, 48% of patient serum samples contained antibodies of at least one isotype to mycobacterial hsp 65. These antibodies were predominantly of IgG and IgM isotype, a finding in contrast to adult rheumatoid arthritis, where IgA and IgG isotypes are most often detected. |
| تدمد: | 1365-3083 0300-9475 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84ec5fe6ac48a869f180b0e6fa4d356 https://doi.org/10.1111/j.1365-3083.1993.tb01697.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d84ec5fe6ac48a869f180b0e6fa4d356 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13653083 03009475 |
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