Elevated Blood Neutrophil-to-Lymphocyte Ratio: A Readily Available Biomarker Associated with Death due to Disease in High Risk Nonmetastatic Melanoma
| العنوان: | Elevated Blood Neutrophil-to-Lymphocyte Ratio: A Readily Available Biomarker Associated with Death due to Disease in High Risk Nonmetastatic Melanoma |
|---|---|
| المؤلفون: | Jeremy L. Davis, Daniel G. Coit, Katherine S. Panageas, Mary S. Brady, Junting Zheng, Michael A. Postow, Charlotte E. Ariyan, Russell C. Langan |
| المصدر: | Annals of Surgical Oncology. 24:1989-1996 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Pathology, Adolescent, Neutrophils, Lymphovascular invasion, Article, Leukocyte Count, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Blood test, Cumulative incidence, Lymphocytes, Neutrophil to lymphocyte ratio, Child, Melanoma, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, business.industry, fungi, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Survival Rate, 030104 developmental biology, Child, Preschool, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Surgery, business, Biomarkers, Follow-Up Studies |
| الوصف: | Elevated peripheral blood neutrophil-to-lymphocyte ratio (NLR) is associated with poor oncologic outcomes in patients with stage IV melanoma and other solid tumors, but its impact has not been characterized for patients with high-risk, nonmetastatic melanoma. Retrospective review of a melanoma database identified patients with high-risk melanoma who underwent operation with curative intent at a single institution. NLR was calculated from blood samples obtained within 2 weeks before operation. Multiple primary melanomas and concurrent hematologic or other metastatic malignancies were excluded. Cumulative incidence of death due to disease was estimated, and Gray’s test was used to examine the effect of NLR on melanoma disease-specific death (DOD). Multivariable competing risks regression models assessed associated factors. Data on 1431 patients with high-risk, nonmetastatic melanoma were analyzed. Median follow-up for survivors was 4 years. High NLR (≥3 or as continuous variable) was associated with older age, male sex, thicker primaries, higher mitotic index, and more advanced nodal status. On multivariate analysis, high NLR (≥3 or as a continuous variable), older age, male sex, ulcerated primary, lymphovascular invasion, and positive nodal status were all independently associated with worse DOD. NLR is a readily available blood test that was independently associated with DOD in patients with high-risk, nonmetastatic melanoma. It is unclear whether high NLR is a passive indicator of poor prognosis or a potential therapeutic target. Further studies to evaluate the prognostic role of NLR to potentially identify those more likely to benefit from adjuvant immunotherapy may prove informative. |
| تدمد: | 1534-4681 1068-9265 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85bdcf88e9ca9730aee38344b38740b https://doi.org/10.1245/s10434-017-5836-0 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d85bdcf88e9ca9730aee38344b38740b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15344681 10689265 |
|---|