Epigenome-wide association study on diffusing capacity of the lung
| العنوان: | Epigenome-wide association study on diffusing capacity of the lung |
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| المؤلفون: | Bruno H. Stricker, Guy Brusselle, George T. O'Connor, Natalie Terzikhan, Hanfei Xu, Lies Lahousse, Josée Dupuis, Ken R. Bracke, Fien M. Verhamme, Ahmed Edris |
| المساهمون: | Epidemiology, Pulmonary Medicine |
| المصدر: | ERJ OPEN RESEARCH ERJ Open Research, 7(1):00567-2020. European Respiratory Society ERJ Open Research, Vol 7, Iss 1 (2021) ERJ Open Research article-version (VoR) Version of Record |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Population, lcsh:Medicine, 03 medical and health sciences, Rotterdam Study, 0302 clinical medicine, Framingham Heart Study, Lung Function, DLCO, Internal medicine, Diffusing capacity, Medicine and Health Sciences, Medicine, Epigenetics, education, 030304 developmental biology, 0303 health sciences, education.field_of_study, Lung, business.industry, lcsh:R, Original Articles, Epigenome, respiratory system, medicine.anatomical_structure, 030228 respiratory system, business |
| الوصف: | Background Epigenetics may play an important role in the pathogenesis of lung diseases. However, little is known about the epigenetic factors that influence impaired gas exchange at the lung. Aim To identify the epigenetic signatures of the diffusing capacity of the lung measured by carbon monoxide uptake (the diffusing capacity of the lung for carbon monoxide (DLCO)). Methods An epigenome-wide association study (EWAS) was performed on diffusing capacity, measured by carbon monoxide uptake (DLCO) and per alveolar volume (VA) (as DLCO/VA), using the single-breath technique in 2674 individuals from two population-based cohort studies. These were the Rotterdam Study (RS, the “discovery panel”) and the Framingham Heart Study (FHS, the “replication panel”). We assessed the clinical relevance of our findings by investigating the identified sites in whole blood and by lung tissue specific gene expression. Results We identified and replicated two CpG sites (cg05575921 and cg05951221) that were significantly associated with DLCO/VA and one (cg05575921) suggestively associated with DLCO. Furthermore, we found a positive association between aryl hydrocarbon receptor repressor (AHRR) gene (cg05575921) hypomethylation and gene expression of exocyst complex component 3 (EXOC3) in whole blood. We confirmed that the expression of EXOC3 in lung tissue is positively associated with DLCO/VA and DLCO. Conclusions We report on epigenome-wide associations with diffusing capacity in the general population. Our results suggest EXOC3 to be an excellent candidate, through which smoking-induced hypomethylation of AHRR might affect pulmonary gas exchange. Epigenetic changes, including smoking-induced hypomethylation, may affect pulmonary gas exchange https://bit.ly/3k4ZdvH |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2312-0541 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88274e6978f31724d8a3e20d954a3e3 https://doi.org/10.1183/23120541.00567-2020 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d88274e6978f31724d8a3e20d954a3e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23120541 |
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