Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke
| العنوان: | Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke |
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| المؤلفون: | Masato Yasui, Humberto Mestre, Nanhong Lou, Hiromu Monai, Kazuko Yahagi, Hajime Hirase, Qiwu Xu, Youichi Iwai, Xiaowen Wang, Yoichiro Abe |
| المصدر: | Proceedings of the National Academy of Sciences. 116:11010-11019 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Adrenergic Antagonists, Adrenergic receptor, Pharmacology, Neuroprotection, Brain Ischemia, Mice, Cerebrospinal fluid, medicine, Extracellular, Animals, Stroke, Aquaporin 4, Multidisciplinary, business.industry, Depolarization, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, PNAS Plus, Astrocytes, Potassium, Female, business, Homeostasis |
| الوصف: | Spontaneous waves of cortical spreading depolarization (CSD) are induced in the setting of acute focal ischemia. CSD is linked to a sharp increase of extracellular K(+) that induces a long-lasting suppression of neural activity. Furthermore, CSD induces secondary irreversible damage in the ischemic brain, suggesting that K(+) homeostasis might constitute a therapeutic strategy in ischemic stroke. Here we report that adrenergic receptor (AdR) antagonism accelerates normalization of extracellular K(+), resulting in faster recovery of neural activity after photothrombotic stroke. Remarkably, systemic adrenergic blockade before or after stroke facilitated functional motor recovery and reduced infarct volume, paralleling the preservation of the water channel aquaporin-4 in astrocytes. Our observations suggest that AdR blockers promote cerebrospinal fluid exchange and rapid extracellular K(+) clearance, representing a potent potential intervention for acute stroke. |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b86faea6f2d7e0b869364357ddca35 https://doi.org/10.1073/pnas.1817347116 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d8b86faea6f2d7e0b869364357ddca35 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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